INT158409

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 9.58
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
beta cell 1
T2DM (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 4 88.32 High High
peripheral neuropathy 6 87.80 High High
Inflammation 30 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 140 100.00 Very High Very High Very High
Chronic Renal Failure 90 100.00 Very High Very High Very High
Cv Unclassified Under Development 50 100.00 Very High Very High Very High
Syndrome 32 100.00 Very High Very High Very High
Calciphylaxis 82 99.84 Very High Very High Very High
Prediabetic State 4 99.76 Very High Very High Very High
Insulin Resistance 12 99.38 Very High Very High Very High
Alzheimer's Dementia 2 99.32 Very High Very High Very High
Calcification 196 99.08 Very High Very High Very High
Autoimmune Disease 4 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review has been an attempt to increase our basic understanding of VOC and its mechanisms in the patient with metS, T2DM, CKD, CHD, and the syndrome of CPLX.
Gene_expression (syndrome) of T2DM associated with calciphylaxis, calcification, chronic renal failure, syndrome, diabetes mellitus and cv unclassified under development
1) Confidence 0.65 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 1.89 Pain Relevance 0
In addition to insulin and IGF-1, there is another beta cell derived islet hormone that is elevated in IR, metS, prediabetes, and early T2DM termed amylin or islet amyloid polypeptide.
Gene_expression (termed) of T2DM in beta cell associated with diabetes mellitus, alzheimer's dementia, prediabetic state and insulin resistance
2) Confidence 0.65 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1079905 Disease Relevance 2.54 Pain Relevance 0
Annp1, 5, 6 and 7 overlapped with reported loci for T1DM (Idd3, 9, 15 and 2, respectively), suggesting that these loci modify not only T1DM but also other autoimmune phenotypes.
Gene_expression (modify) of T1DM associated with diabetes mellitus
3) Confidence 0.15 Published 2009 Journal Int. Immunol. Section Abstract Doc Link 19261693 Disease Relevance 2.47 Pain Relevance 0.28
Annp1, 5, 6 and 7 overlapped with reported loci for T1DM (Idd3, 9, 15 and 2, respectively), suggesting that these loci modify not only T1DM but also other autoimmune phenotypes.
Gene_expression (loci) of T1DM associated with diabetes mellitus
4) Confidence 0.15 Published 2009 Journal Int. Immunol. Section Abstract Doc Link 19261693 Disease Relevance 2.68 Pain Relevance 0.28

General Comments

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