INT158410

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.73
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Pdcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 2 95.36 Very High Very High Very High
peripheral neuropathy 3 95.10 Very High Very High Very High
cytokine 14 56.28 Quite High
agonist 12 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 17 99.80 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 148 98.94 Very High Very High Very High
Autoimmune Disease 2 98.90 Very High Very High Very High
Infection 36 98.80 Very High Very High Very High
Increased Venous Pressure Under Development 1 97.46 Very High Very High Very High
Sialadenitis 3 96.86 Very High Very High Very High
Gastritis 2 96.32 Very High Very High Very High
Neuritis 2 95.36 Very High Very High Very High
Peripheral Neuropathy 3 95.10 Very High Very High Very High
Disease 24 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified seven QTLs for peripheral neuropathy and neuritis, one QTL for insulitis, four QTLs for gastritis, two QTLs for sialadenitis and seven QTLs for vasculitis throughout the genome and designated them as Annp loci for autoimmunity due to polymorphisms of non-MHC genes in NOD mice and PD-1 deficiency.
Negative_regulation (deficiency) of PD-1 associated with autoimmune disease, diabetes mellitus, sialadenitis, peripheral neuropathy, increased venous pressure under development, gastritis and neuritis
1) Confidence 0.37 Published 2009 Journal Int. Immunol. Section Abstract Doc Link 19261693 Disease Relevance 2.75 Pain Relevance 0.30
In these studies, TCR and CD28 signals sufficed to rescue CD8 in exhaustion, once PD-1 activity was blocked [17].
Negative_regulation (blocked) of PD-1
2) Confidence 0.05 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.44 Pain Relevance 0
It remains to be determined if the exhausted condition of CD8 towards parasite antigens is a cause or a consequence of the progressive infection of DCL patients by Leishmania mexicana and if TLR2 induces downregulation of PD-1 pathway.
Negative_regulation (downregulation) of PD-1 associated with diffuse cutaneous leishmaniasis and infection
3) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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