INT15842

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Context Info
Confidence 0.73
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.00
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, Pomc) extracellular space (Crh, Pomc) extracellular region (Crh, Pomc)
cell-cell signaling (Pomc) response to stress (Crh) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
white blood cells 4
neurons 4
hypothalamus 2
brain 2
MCG 2
Crh (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 13 100.00 Very High Very High Very High
Pain 2 99.52 Very High Very High Very High
opiate 3 99.48 Very High Very High Very High
narcan 11 99.26 Very High Very High Very High
electroacupuncture 136 99.12 Very High Very High Very High
Endogenous opioid 2 97.32 Very High Very High Very High
cva 22 96.52 Very High Very High Very High
Opioid 12 96.08 Very High Very High Very High
Central nervous system 1 94.52 High High
ischemia 2 92.28 High High
Disease Link Frequency Relevance Heat
Pain 3 99.52 Very High Very High Very High
Stress 23 98.76 Very High Very High Very High
Lordosis 12 98.02 Very High Very High Very High
Cv General 4 Under Development 24 96.52 Very High Very High Very High
Vascular Disease 2 95.96 Very High Very High Very High
Hyperalgesia 28 91.20 High High
Increased Venous Pressure Under Development 12 90.48 High High
Urological Neuroanatomy 8 81.36 Quite High
INFLAMMATION 26 81.04 Quite High
Pressure And Volume Under Development 24 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRF was found to stimulate beta-endorphin and dynorphin release from hypothalami from intact and from 1- and 4-week-castrated rats, a result indicating that castration does not alter the response of beta-endorphin and dynorphin neurons to this stimulus.
CRF Positive_regulation (stimulate) of Localization (release) of beta-endorphin in neurons associated with dynorphin
1) Confidence 0.73 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2886553 Disease Relevance 0 Pain Relevance 0.30
Corticotropin-releasing factor (CRF) at doses of 10(-12)-10(-8) M significantly stimulated the release of beta-endorphin and dynorphin from superfused rat hypothalamic slices.
CRF Positive_regulation (stimulated) of Localization (release) of beta-endorphin associated with dynorphin
2) Confidence 0.49 Published 1986 Journal Brain Res. Section Abstract Doc Link 2879612 Disease Relevance 0 Pain Relevance 0.21
Corticotropin-releasing factor (CRF) at doses of 10(-12)-10(-8) M significantly stimulated the release of beta-endorphin and dynorphin from superfused rat hypothalamic slices.
Corticotropin-releasing factor Positive_regulation (stimulated) of Localization (release) of beta-endorphin associated with dynorphin
3) Confidence 0.49 Published 1986 Journal Brain Res. Section Abstract Doc Link 2879612 Disease Relevance 0 Pain Relevance 0.21
These results suggest that i.c.v. administration of beta-endorphin stimulates the secretion of ACTH, E, and NE through opiate receptor, and that brain CRH mediates the beta-endorphin-induced secretion of ACTH.
CRH Positive_regulation (mediates) of Localization (secretion) of beta-endorphin-induced in brain associated with opiate
4) Confidence 0.38 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449422 Disease Relevance 0.40 Pain Relevance 0.45
Thus, the inhibition of lordosis by CRF and the complete reversal of this blockade by naloxone or anti-beta-end-G may suggest that CRF could enhance the release of beta-endorphin from fibres in the MCG; beta-endorphin then inhibits lordosis by inhibiting the release of GnRH.
CRF Positive_regulation (enhance) of Localization (release) of beta-endorphin in MCG associated with narcan and lordosis
5) Confidence 0.38 Published 1985 Journal Brain Res. Section Abstract Doc Link 2860950 Disease Relevance 0.78 Pain Relevance 0.44
Corticotropin-releasing factor initially stimulates the release of beta-endorphin and dynorphin from rat hypothalamic slices in vitro; with time, in the continued presence of corticotropin-releasing factor, the release of both these peptides declines.
Corticotropin-releasing factor Positive_regulation (stimulates) of Localization (release) of beta-endorphin associated with dynorphin
6) Confidence 0.37 Published 1987 Journal Neuroscience Section Abstract Doc Link 2891081 Disease Relevance 0 Pain Relevance 0.29
Corticotropin releasing hormone (CRH) induces the release of beta-endorphin (beta-END) from hypothalamic neurons and also from mononuclear white blood cells.
CRH Positive_regulation (induces) of Localization (release) of beta-endorphin in white blood cells
7) Confidence 0.16 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10574471 Disease Relevance 1.16 Pain Relevance 0.47
Corticotropin releasing hormone (CRH) induces the release of beta-endorphin (beta-END) from hypothalamic neurons and also from mononuclear white blood cells.
Corticotropin releasing hormone Positive_regulation (induces) of Localization (release) of beta-endorphin in white blood cells
8) Confidence 0.16 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10574471 Disease Relevance 1.17 Pain Relevance 0.47
These results Indicate that the central administration of NPY increases the CRF mRNA levels in the hypothalamus and the probable CRF release, which increases the proopiomelanocortin mRNA levels and ACTH secretion in the anterior pituitary.
CRF Positive_regulation (increases) of Localization (secretion) of proopiomelanocortin mRNA in hypothalamus
9) Confidence 0.15 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8392133 Disease Relevance 0 Pain Relevance 0.14
Recent in vitro studies have shown that the release of hypothalamic beta-endorphin (beta-END), like that of adenohypophysial origin, is enhanced by both corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP).
CRH Positive_regulation (enhanced) of Localization (release) of beta-endorphin
10) Confidence 0.12 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0
Recent in vitro studies have shown that the release of hypothalamic beta-endorphin (beta-END), like that of adenohypophysial origin, is enhanced by both corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP).
corticotropin-releasing hormone Positive_regulation (enhanced) of Localization (release) of beta-endorphin
11) Confidence 0.12 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0
So, it is hypothesized that EA activates CRH neurons in the PVN to secret CRH, which in turn stimulates the release of beta-endorphin to inhibit pain.
CRH Positive_regulation (stimulates) of Localization (release) of beta-endorphin in neurons associated with pain and electroacupuncture
12) Confidence 0.08 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2408560 Disease Relevance 0.83 Pain Relevance 1.64
By stimulating the release of adrenocorticotropin hormone (ACTH), CRF acts as a key mediator of the stress response.
CRF Positive_regulation (stimulating) of Localization (release) of adrenocorticotropin hormone associated with stress
13) Confidence 0.06 Published 2003 Journal Brain Res. Section Abstract Doc Link 12885425 Disease Relevance 0.53 Pain Relevance 0.25
In addition to corticotropin-releasing factor (CRF) and structurally related peptides, arginine vasopressin (AVP), oxytocin, angiotensin II, vasoactive intestinal polypeptide, peptide histidine isoleucinamide, epinephrine (E), and norepinephrine induce secretion of adrenocorticotropin (ACTH) from corticotropic cells in vitro.
CRF Positive_regulation (induce) of Localization (secretion) of adrenocorticotropin
14) Confidence 0.02 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981737 Disease Relevance 0.14 Pain Relevance 0.04
Angiotensin II and adrenocorticotropin release: mediation by endogenous corticotropin-releasing factor.
corticotropin-releasing factor Positive_regulation (mediation) of Localization (release) of adrenocorticotropin
15) Confidence 0.01 Published 1986 Journal Endocrinology Section Title Doc Link 3015575 Disease Relevance 0 Pain Relevance 0.13

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