INT158426

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.95
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
Notch 5
respiratory 2
B-cell 1
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 2 78.40 Quite High
Neuritis 1 74.64 Quite High
Angina 10 65.40 Quite High
cytokine 5 64.08 Quite High
metalloproteinase 4 62.88 Quite High
vincristine 1 55.52 Quite High
Neurotransmitter 2 43.20 Quite Low
imagery 3 38.24 Quite Low
ketamine 4 33.44 Quite Low
anesthesia 3 32.72 Quite Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 361 100.00 Very High Very High Very High
Infection 108 100.00 Very High Very High Very High
Sprains And Strains 71 100.00 Very High Very High Very High
Cancer 215 99.98 Very High Very High Very High
Respiratory Disease 6 98.88 Very High Very High Very High
Fever 13 97.68 Very High Very High Very High
Metastasis 16 95.12 Very High Very High Very High
Adhesions 7 91.16 High High
Hodgkin's Disease 220 89.84 High High
Malignant Neoplastic Disease 11 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mediators have been joined by others including Notch/Delta, semaphorin, ephrin,
Notch Binding (ephrin) of in Notch
1) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.55 Pain Relevance 0.04
Notch proteins are definitely recognized as key regulators of the neuronal fate during embryo development, but their function in the adult brain is still largely unknown.
Notch Binding (recognized) of in Notch
2) Confidence 0.35 Published 2009 Journal Dev Neurobiol Section Abstract Doc Link 19263417 Disease Relevance 0.26 Pain Relevance 0.07
As summarized in Table 4, the markers include several signaling proteins, some of them previously implicated in cancer transformation (Notch signaling, Wnt signaling, TGF-?
Notch Binding (transformation) of in Notch associated with cancer
3) Confidence 0.07 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.04 Pain Relevance 0.03
Finally, Notch 1, a transcription factor that promotes T-cell development and inhibits B-cell development of lymphoid precursors, downregulates expression of E2A and EBF, induces ABF1, and binds to Pax5 in HRS tumor cells.
Notch 1 Binding (binds) of in B-cell associated with cancer
4) Confidence 0.06 Published 2011 Journal Advances in Hematology Section Body Doc Link PMC2994062 Disease Relevance 0.86 Pain Relevance 0.03
It interacts with Notch cell surface receptors to act as a negative feedback inhibitor downstream of VEGF signaling to restrain the sprouting and branching of new blood vessels [10,12].
Notch Binding (interacts) of in Notch
5) Confidence 0.04 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.41 Pain Relevance 0
Little information is available on immune responses after infection with influenza virus H5N1 in cats.
H5N1 Binding (infection) of associated with influenza virus infection and infection
6) Confidence 0.03 Published 2007 Journal Emerging Infectious Diseases Section Body Doc Link PMC2725870 Disease Relevance 0.86 Pain Relevance 0
In the case of Notch, the process is set in motion by the binding of a ligand to the Notch ectodomain, triggering its release (shedding).
Notch Binding (binding) of in Notch
7) Confidence 0.01 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.03
While the exact Sia residues recognized by these emerging strains (pandemic influenza A(H1N1) or HPAI) may vary, DAS181 exhibits broad spectrum sialic acid removal and therefore may be effective against current and future influenza viruses with altered HA-Sia binding specificity.
H1N1 Binding (recognized) of associated with influenza virus infection and sprains and strains
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770640 Disease Relevance 0.84 Pain Relevance 0
The effective inhibitory DAS181 concentration for the pandemic influenza A(H1N1) viruses was similar to that with seasonal IFV, suggesting that the pandemic influenza A(H1N1) viruses binds to sialic acid residues comparably recognized by DAS181.
H1N1 Binding (binds) of associated with influenza virus infection
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770640 Disease Relevance 1.13 Pain Relevance 0
A broad case definition permitted inclusion of influenza cases that might otherwise go undetected; for example, requirement of fever in the case definition for severe acute respiratory disease could miss a significant proportion of serious illness associated with both seasonal H1N1 and pH1N1.
H1N1 Binding (associated) of in respiratory associated with influenza virus infection, respiratory disease and fever
10) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012722 Disease Relevance 1.01 Pain Relevance 0.12
A broad case definition permitted inclusion of influenza cases that might otherwise go undetected; for example, requirement of fever in the case definition for severe acute respiratory disease could miss a significant proportion of serious illness associated with both seasonal H1N1 and pH1N1.
pH1N1 Binding (associated) of in respiratory associated with influenza virus infection, respiratory disease and fever
11) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012722 Disease Relevance 1.01 Pain Relevance 0.12

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