INT158440

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.22
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Nsdhl) endoplasmic reticulum (Nsdhl)
Anatomy Link Frequency
spine 1
nucleus 1
Nsdhl (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 5 98.16 Very High Very High Very High
Glutamate 3 96.04 Very High Very High Very High
Analgesic 3 80.44 Quite High
Inflammation 3 79.88 Quite High
Dopamine 35 78.24 Quite High
midbrain 6 70.32 Quite High
Anterior cingulate cortex 1 69.28 Quite High
Bile 8 69.00 Quite High
anesthesia 1 51.40 Quite High
isoflurane 1 50.96 Quite High
Disease Link Frequency Relevance Heat
Ascariasis 34 100.00 Very High Very High Very High
Abscess 6 99.20 Very High Very High Very High
Helminth Infection 59 98.64 Very High Very High Very High
Schizophrenia 220 97.98 Very High Very High Very High
Cirrhosis 9 97.36 Very High Very High Very High
Alzheimer's Dementia 1 95.48 Very High Very High Very High
Toxicity 4 94.64 High High
Recurrence 6 92.32 High High
Infection 2 86.72 High High
Congenital Anomalies 45 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pumps delivered BPA or vehicle until PND2.
Negative_regulation (delivered) of BPA
1) Confidence 0.21 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.08 Pain Relevance 0.08
The mitogen-activated kinase (MAPK) cascade likely influences estrogen-induced CA1 pyramidal dendrite spine synapse density109 and may be involved in the pathogenesis of schizophrenia.110 BPA exposure in rats impairs estrogen-induced hippocampal synaptogenesis that may occur through inhibition of MAPK.109 BPA also exerts estrogenic protective effects on hippocampus cells, providing neuroprotection against glutamate and amyloid beta protein toxicity.111
Negative_regulation (inhibition) of BPA in spine associated with toxicity, glutamate, alzheimer's dementia, hippocampus and schizophrenia
2) Confidence 0.18 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.18 Pain Relevance 0.25
In conclusion, biliary ascariasis associated with dead worms is more common amongst males than females, but females are greater sufferers of BPA.
Negative_regulation (sufferers) of BPA associated with helminth infection and ascariasis
3) Confidence 0.04 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003205 Disease Relevance 1.80 Pain Relevance 0.03
From the DFT results, various quantum chemical based descriptors were computed but the QSAR results showed that the descriptors based on frontier electron density and a new DFT based quantum chemical descriptor, nucleus independent chemical shift (NICS) are likely to be responsible for the in vitro inhibiting activity of BPA and MPBA.
Negative_regulation (inhibiting) of BPA in nucleus
4) Confidence 0.02 Published 2009 Journal J Mol Model Section Abstract Doc Link 19266221 Disease Relevance 0.15 Pain Relevance 0.16

General Comments

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