INT158442

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 8.47
Pain Relevance 1.99

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nucleoplasm (Nkx2-1) anatomical structure formation involved in morphogenesis (Nkx2-1) nucleus (Nkx2-1)
DNA binding (Nkx2-1) transcription factor binding (Nkx2-1)
Anatomy Link Frequency
thyroid 4
telencephalon 3
lung epithelium 2
neuronal 2
neuron 2
Nkx2-1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 408 100.00 Very High Very High Very High
amygdala 458 96.96 Very High Very High Very High
Thoracotomy 1 88.60 High High
Nucleus accumbens 12 85.92 High High
imagery 10 81.64 Quite High
Pain 6 80.16 Quite High
backache 1 79.60 Quite High
abdominal pain 2 78.96 Quite High
parabrachial 36 45.52 Quite Low
Spinal cord 24 43.76 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 19 100.00 Very High Very High Very High
Interstitial Lung Diseases 143 99.78 Very High Very High Very High
Cancer 128 99.52 Very High Very High Very High
Small Cell Lung Cancer 240 98.28 Very High Very High Very High
Sarcoma 4 96.64 Very High Very High Very High
Disease 87 96.32 Very High Very High Very High
Primitive Neuroectodermal Tumors 4 96.00 Very High Very High Very High
Malignant Neoplastic Disease 16 95.04 Very High Very High Very High
Skin Cancer 48 93.92 High High
Carcinoma 6 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTF-1 was a newly described nuclear transcriptional factor expressed in epithelial cells of thyroid and lung and in a high proportion of SCC.
Gene_expression (expressed) of TTF-1 in thyroid associated with small cell lung cancer
1) Confidence 0.59 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1829164 Disease Relevance 1.32 Pain Relevance 0
Thyroid transcription factor 1 (known as TTF-1, NKx2.1, or T/EBP) is a homeodomain-containing transcription factor expressed in thyroid and lung epithelium and in restricted regions of the fetal brain (Lazzaro et al., 1991).
Gene_expression (expressed) of T/EBP in lung epithelium
2) Confidence 0.58 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2951178 Disease Relevance 0 Pain Relevance 0
Histologic features were observed and immunohistochemical detection of cytokeratin (CK), epithelial membrane antigen (EMA), neuron specific enolase (NSE), synaptophysin (Syn), chromogranin A (CgA), neuronal cell adhesion molecules (CD56), thyroid transcriptional factor-1 (TTF-1) and S100 protein (S100) was performed.


Gene_expression (detection) of TTF-1 in neuron associated with adhesions
3) Confidence 0.46 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1829164 Disease Relevance 1.06 Pain Relevance 0
Histologic features were observed and immunohistochemical detection of cytokeratin (CK), epithelial membrane antigen (EMA), neuron specific enolase (NSE), synaptophysin (Syn), chromogranin A (CgA), neuronal cell adhesion molecules (CD56), thyroid transcriptional factor-1 (TTF-1) and S100 protein (S100) was performed.


Gene_expression (detection) of thyroid transcriptional factor-1 in neuron associated with adhesions
4) Confidence 0.46 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1829164 Disease Relevance 1.05 Pain Relevance 0
TTF-1 was a newly described nuclear transcriptional factor expressed in epithelial cells of thyroid and lung and in a high proportion of SCC.
Gene_expression (expressed) of TTF-1 in lung associated with small cell lung cancer
5) Confidence 0.20 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1829164 Disease Relevance 1.32 Pain Relevance 0
Thyroid transcription factor 1 (known as TTF-1, NKx2.1, or T/EBP) is a homeodomain-containing transcription factor expressed in thyroid and lung epithelium and in restricted regions of the fetal brain (Lazzaro et al., 1991).
Gene_expression (expressed) of T/EBP in thyroid
6) Confidence 0.20 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2951178 Disease Relevance 0 Pain Relevance 0
Another contributor of ILD is TTF-1 (NK2 homeobox 1) dysfunction.
Gene_expression (dysfunction) of NK2 homeobox 1 associated with interstitial lung diseases
7) Confidence 0.07 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 0.48 Pain Relevance 0
Neoplastic cells were strongly immunoreactive for CD99 and vimentin and were negative for chromogranin, synaptophysin, CD31, CD34, calcitonin, desmin, low-molecular weight cytokeratins, wide-spectrum cytokeratins, leukocyte common antigen, S-100 protein, and thyroid transcription factor-1.
Neg (negative) Gene_expression (negative) of thyroid transcription factor-1 in thyroid
8) Confidence 0.06 Published 2008 Journal Tumori Section Abstract Doc Link 19267114 Disease Relevance 1.48 Pain Relevance 0.16
Immunohistochemical staining of chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin (Syn), neuronal cell adhesion molecules (CD56), thyroid transcription factor-1 (TTF-1), cytokeration 34betaE12 (CK34betaE12), cytokeratin (AE1/AE3), and cytokeratin 10/13 was performed.
Gene_expression (/) of thyroid transcription factor-1 in neuronal associated with adhesions
9) Confidence 0.05 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.88 Pain Relevance 0.16
Immunohistochemical staining of chromogranin A (CgA), neuron-specific enolase (NSE), synaptophysin (Syn), neuronal cell adhesion molecules (CD56), thyroid transcription factor-1 (TTF-1), cytokeration 34betaE12 (CK34betaE12), cytokeratin (AE1/AE3), and cytokeratin 10/13 was performed.
Gene_expression (staining) of thyroid transcription factor-1 in neuronal associated with adhesions
10) Confidence 0.05 Published 2010 Journal Dis. Esophagus Section Abstract Doc Link 19515193 Disease Relevance 0.89 Pain Relevance 0.15
Our results in Pleurodeles clearly demonstrate the pallidal nature of this area, based on the Nkx2.1 expression pattern, making it impossible to establish homologies with the basolateral amygdala (with a pallial nature) or with the CeA (with a striatal origin).
Gene_expression (expression) of Nkx2.1 in amygdala associated with amygdala
11) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.17
We found that Nkx2.1, Isl1, GABA, and NOS are expressed in unique and conserved patterns that mark specific regions of the telencephalon.
Gene_expression (expressed) of Nkx2.1 in telencephalon associated with gaba
12) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.12
Thyroid transcription factor 1 (known as TTF-1, Nkx2.1, or T/EBP) is a homeodomain containing transcription factor expressed in thyroid and lung epithelium and in restricted regions of the fetal brain (Kimura et al., 1996; Lazzaro et al., 1991).
Gene_expression (expressed) of Nkx2.1 in lung epithelium
13) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.21
In addition, previous studies in developing Xenopus using in situ hybridization (Bachy et al., 2002) and immunohistochemistry with this antibody (Bachy and Rétaux, 2006) to evidence the Nkx2.1 expression have demonstrated the fully comparable results with both techniques.
Gene_expression (expression) of Nkx2.1
14) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0
In particular, the pallidal component is revealed by Nkx2.1 expression, which is also directly involved in the patterning of the subpallial telencephalon and hypothalamus (Marín et al., 2002; Shimamura and Rubenstein, 1997; Sussel et al., 1999).
Gene_expression (expression) of Nkx2.1 in telencephalon
15) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.09
Our results in Pleurodeles are consistent with those described in other tetrapods; thus Nkx2.1 is expressed by virtually all the MGE cells and scattered cells were also detected in LGE territories that most likely correspond to migrated cells from the MGE, like in amniotes and anurans (Bachy and Rétaux, 2006; Marín et al., 2000).
Gene_expression (expressed) of Nkx2.1
16) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.06
Regional markers: telencephalic expression of NOS, Isl1, GABA, and Nkx2.1
Gene_expression (expression) of Nkx2.1 in telencephalic associated with gaba
17) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.20
In all tetrapods studied, Nkx2.1 is expressed in both progenitor and postmitotic cells and its expression is often maintained into adulthood, suggesting it has a role both in the specification of precursors and in the differentiation or maintenance of the phenotype mature ventral forebrain cells (Bachy et al., 2002; González et al., 2002a; González et al., 2002b; Marín et al., 2000; Puelles et al., 2000).
Gene_expression (expressed) of Nkx2.1 in ventral
18) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.08
However, given the expression of Nkx2.1 and NOS (present results; Moreno et al., 2002) and the data from anurans during development (González et al., 2002a; González et al., 2002b; López and González, 2002; Moreno et al., 2004; Moreno and González, 2007b), we can state at least that the amphibian MeA is an olfactory/vomeronasal structure situated in the pallio–subpallio boundary much more complex than previously thought, containing cells expressing subpallial markers and, from late developmental stages, cells that express some pallial markers.
Gene_expression (expression) of Nkx2.1 in olfactory associated with amygdala
19) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.17
Neurons expressing the transcription factor Nkx2.1 were mainly located in the ventromedial telencephalon (Figure 2d,d?).
Gene_expression (expressing) of Nkx2.1 in telencephalon
20) Confidence 0.01 Published 2007 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2525920 Disease Relevance 0 Pain Relevance 0.13

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