INT158444

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.00
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cnp) plasma membrane (Cnp) intracellular (Cnp)
cytoplasm (Cnp)
Anatomy Link Frequency
corpus callosum 1
striatum 1
gastric smooth muscle 1
white matter 1
Cnp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 56 92.64 High High
Central nervous system 2 85.92 High High
Demyelination 6 71.12 Quite High
abdominal pain 1 64.60 Quite High
nud 3 63.60 Quite High
excitatory amino acid 2 34.00 Quite Low
Neurotransmitter 2 25.68 Quite Low
Hippocampus 6 25.60 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
bDMF 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 14 98.92 Very High Very High Very High
Middle Cerebral Artery Infarction 62 98.82 Very High Very High Very High
Stroke 172 96.78 Very High Very High Very High
Targeted Disruption 4 95.44 Very High Very High Very High
Brain Hemorrhage 12 94.12 High High
Hypoxia 18 93.24 High High
Cv Unclassified Under Development 44 92.64 High High
Hyperplasia 2 89.96 High High
Gastric Motility Disorder 5 85.12 High High
Natriuresis 6 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, using in vivo measurement of diffusion anisotropy which detects axonal tract integrity within white matter after stroke [36], we previously demonstrated that treatment with rhEPO enhanced axonal density around peri-infarct region starting 4 weeks, a time point when a substantial increase in CNPase immunoreactivity was detected in the present study [37].
Positive_regulation (increase) of CNPase in white matter associated with stroke
1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.51 Pain Relevance 0.03
The pGC activity in response to CNP and cGMP production in gastric smooth muscle were measured by using radioimmunoassay (RIA) in normal and diabetic rats.
Positive_regulation (response) of CNP in gastric smooth muscle associated with diabetes mellitus
2) Confidence 0.48 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19267196 Disease Relevance 1.69 Pain Relevance 0.16
Our data show that EPO-increased CNPase immunoreactivity was closely associated with NF-H positive axons and that EPO augmented myelinated axons measured by Bielschowsky and Luxol fast blue positive axons.
Positive_regulation (increased) of CNPase
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 1.00 Pain Relevance 0.09
Twenty-eight and 42 days after MCAo, ischemic rats treated with rhEPO exhibited a significant increase in CNPase and MBP immunoreactivity along the peri-infarct corpus callosum and striatum compared to the ischemic rats treated with saline (Fig. 2 and 4).
Positive_regulation (increase) of CNPase in striatum associated with middle cerebral artery infarction
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.53 Pain Relevance 0.03
The result of present study also showed that increased BrdU-positive cells in ischemic penumbra and SVZ of the LV in r-Hu-EPO-treated ischemic rats are associated with significantly increased CNPase-immunoreactive cells which are identified as OPCs (Ness et al., 2005).
Positive_regulation (increased) of CNPase
5) Confidence 0.30 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0.48 Pain Relevance 0.20
However, a strong increase in immunoreactivity of CNPase was detected in the ipsilateral SVZ of the LV after r-Hu-EPO treatment as compared with that of I-R (Fig. 3C, I-R+EPO).
Positive_regulation (increase) of CNPase
6) Confidence 0.28 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0.24 Pain Relevance 0
Twenty-eight and 42 days after MCAo, ischemic rats treated with rhEPO exhibited a significant increase in CNPase and MBP immunoreactivity along the peri-infarct corpus callosum and striatum compared to the ischemic rats treated with saline (Fig. 2 and 4).
Positive_regulation (increase) of CNPase in corpus callosum associated with middle cerebral artery infarction
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.53 Pain Relevance 0.03

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