INT158445

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Npr2) plasma membrane (Npr2)
Anatomy Link Frequency
gonadotrophs 1
gastric smooth muscles 1
Npr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 9 68.24 Quite High
Kinase C 1 54.80 Quite High
abdominal pain 1 34.52 Quite Low
nud 3 33.52 Quite Low
antagonist 40 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
agonist 24 5.00 Very Low Very Low Very Low
cytokine 23 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 13 99.48 Very High Very High Very High
Diabetes Mellitus 18 98.24 Very High Very High Very High
Hypoxia 146 58.56 Quite High
Gastric Motility Disorder 5 55.04 Quite High
Targeted Disruption 22 44.88 Quite Low
Abdominal Pain 1 34.52 Quite Low
Dyspepsia 3 33.52 Quite Low
Vomiting 2 32.20 Quite Low
Stress 53 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Natriuretic peptide receptor type B (NPR-B) gene was expressed in the gastric smooth muscles of normal and diabetic rats, and the expression was increased in diabetic rats.
Gene_expression (expressed) of NPR-B in gastric smooth muscles associated with natriuresis and diabetes mellitus
1) Confidence 0.36 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19267196 Disease Relevance 1.08 Pain Relevance 0
Ten were not represented (AKAP9, BAIAP1, CASR, DLG2, EPHB4, GRIN3B, GUCY2C, GUCY2D, NPR2, and PRKCABP).
Neg (not) Gene_expression (represented) of NPR2
2) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.11 Pain Relevance 0.12
Since the GC-B mRNA is detectable in gonadotrophs, CNP is a candidate autocrine regulator of gonadotrophs (192).
Gene_expression (detectable) of GC-B mRNA in gonadotrophs
3) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.03

General Comments

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