INT15845

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Context Info
Confidence 0.05
First Reported 1986
Last Reported 1995
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.76
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
POA 2
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 11 100.00 Very High Very High Very High
agonist 2 99.98 Very High Very High Very High
antagonist 1 99.52 Very High Very High Very High
opiate 1 99.28 Very High Very High Very High
Pain 6 97.72 Very High Very High Very High
narcan 13 93.20 High High
Hyperalgesia 1 90.24 High High
Endogenous opioid 2 86.16 High High
anesthesia 2 77.04 Quite High
GABAergic 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 5 97.72 Very High Very High Very High
Anxiety Disorder 3 97.36 Very High Very High Very High
Hyperalgesia 1 90.24 High High
Stress 1 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both ADX and CB replacement significantly reduced the stimulatory effect of CRH (10(-8) M) upon beta-END release.
Negative_regulation (reduced) of Localization (release) of beta-END
1) Confidence 0.05 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0.06
However, the AVP-stimulated release of beta-END was completely abolished in ADX rats treated with a high dose of CB.
Negative_regulation (abolished) of Localization (release) of beta-END
2) Confidence 0.05 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0.07
Results indicate that opiate antagonists stimulate and agonists suppress the release of i beta-END, possibly by affecting the patient's perceived level of pain and anxiety.
Spec (possibly) Negative_regulation (suppress) of Localization (release) of beta-END associated with pain, antagonist, anxiety disorder, agonist and opiate
3) Confidence 0.01 Published 1986 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3731680 Disease Relevance 0.76 Pain Relevance 1.11
In rats, beta-endorphin (beta-END) and gamma-aminobutyric acid (GABA) suppress LH secretion by hypothalamic mechanisms involving the preoptic area (POA).
Negative_regulation (suppress) of Localization (secretion) of beta-END in POA associated with gaba
4) Confidence 0.00 Published 1995 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 8536061 Disease Relevance 0 Pain Relevance 0.47

General Comments

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