INT158452

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.16
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (GIT1)
Anatomy Link Frequency
trunk 1
GIT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 16 99.84 Very High Very High Very High
Potency 2 89.00 High High
antinociception 4 81.64 Quite High
analgesia 2 75.00 Quite High
tail-flick 2 69.00 Quite High
Serotonin 2 65.48 Quite High
monoamine 2 63.40 Quite High
Opioid 2 62.64 Quite High
Antinociceptive 2 57.96 Quite High
Pain 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Metastasis 36 99.96 Very High Very High Very High
Melanoma 39 98.36 Very High Very High Very High
Recurrence 3 71.12 Quite High
Necrosis 1 60.80 Quite High
Freckles 1 59.76 Quite High
Cancer 20 57.84 Quite High
Disease 4 22.64 Low Low
Weight Loss 1 20.08 Low Low
Abdominal Pain 1 19.48 Low Low
Hemorrhage 1 18.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to the literature, our patient presented all of the major risk factors for developing GIT metastases: the location of the primary melanoma on the trunk, high Clark level and Breslow thickness, and a nodular type of lesion.
Negative_regulation (developing) of GIT in trunk associated with melanoma and metastasis
1) Confidence 0.22 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396655 Disease Relevance 1.16 Pain Relevance 0
Using a fixed-dose protocol, we could demonstrate antagonism between DEX and TRAM on the inhibition of GIT.
Negative_regulation (inhibition) of GIT associated with tramadol
2) Confidence 0.11 Published 2009 Journal Fundam Clin Pharmacol Section Abstract Doc Link 19267773 Disease Relevance 0 Pain Relevance 1.04
On the inhibition of GIT, a dose-related inhibition was established for TRAM, but not for DEX.
Negative_regulation (inhibition) of GIT associated with tramadol
3) Confidence 0.11 Published 2009 Journal Fundam Clin Pharmacol Section Abstract Doc Link 19267773 Disease Relevance 0 Pain Relevance 1.09

General Comments

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