INT158458

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Context Info
Confidence 0.02
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.73
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp23) endoplasmic reticulum (Mmp23)
Anatomy Link Frequency
fibroblasts 2
Mmp23 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 100.00 Very High Very High Very High
tolerance 4 69.60 Quite High
Inflammation 18 68.68 Quite High
cytokine 7 66.52 Quite High
fibrosis 2 50.00 Quite Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 56 98.96 Very High Very High Very High
Oral Submucous Fibrosis 2 93.56 High High
Alzheimer's Dementia 32 92.72 High High
Amyloid Plaque 12 88.96 High High
Fibrosarcoma 4 83.36 Quite High
Stress 11 72.64 Quite High
Death 4 72.04 Quite High
Familial Amyloidotic Polyneuropathy 21 69.32 Quite High
INFLAMMATION 24 68.68 Quite High
Targeted Disruption 8 61.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Primary mice oral fibroblasts were cultured, the effects of borneol on fibroblasts proliferation, cytotoxicity, collagen production, matrix metalloproteinases-2,9 (MMP-2,9) activities and tissue inhibitors of metalloproteinase 1 (TIMP-1) production were tested by methyl thiazolyl tetrazolium assay, lactic dehydrogenase activity assay, chloramine T method, gelatin zymography and enzyme-linked immunosorbent assay, respectively.
Regulation (effects) of Gene_expression (production) of metalloproteinase in fibroblasts
1) Confidence 0.02 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.09 Pain Relevance 0
TUDCA treatment did not alter the levels of this metalloproteinase which was equivalent to control non-treated animals.
Neg (not) Regulation (alter) of Gene_expression (levels) of metalloproteinase associated with metalloproteinase
2) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.96 Pain Relevance 0.05
Overexpression of IDO or inhibition of endogenous IDO expression was accompanied by changes in metalloproteinase expression and also in the expression and activity of the cyclooxygenase enzymes.
Regulation (changes) of Gene_expression (expression) of metalloproteinase associated with metalloproteinase
3) Confidence 0.01 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC31925 Disease Relevance 0.50 Pain Relevance 0.15
IDO axpression alters metalloproteinase expression
Regulation (alters) of Gene_expression (expression) of metalloproteinase associated with metalloproteinase
4) Confidence 0.01 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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