INT158459

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.21
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
fibroblasts 4
chondrocytes 2
lungs 2
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 213 100.00 Very High Very High Very High
fibrosis 128 99.88 Very High Very High Very High
Chronic pancreatitis 1 94.40 High High
Pain 7 83.76 Quite High
rheumatoid arthritis 2 81.40 Quite High
Inflammation 115 79.32 Quite High
Arthritis 3 72.88 Quite High
analgesia 1 65.12 Quite High
cytokine 18 62.72 Quite High
Versed 1 60.08 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 65 99.88 Very High Very High Very High
Uveitis 44 96.80 Very High Very High Very High
Systemic Sclerosis 67 96.32 Very High Very High Very High
Pancreatitis 2 94.40 High High
Fibrosis 69 94.24 High High
Cirrhosis 3 93.36 High High
Asthma 3 92.08 High High
Interstitial Lung Diseases 7 89.12 High High
Pulmonary Disease 9 85.84 High High
Systemic Lupus Erythematosus 1 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover borneol could significantly (P < 0.05) decrease MMP-2 activity, and very significantly (P < 0.01) inhibit TIMP-1 production.
Negative_regulation (inhibit) of Gene_expression (production) of TIMP-1
1) Confidence 0.40 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.06 Pain Relevance 0
In humans, increased levels of TIMP protein and RNA are observed in lungs of patients with idiopathic pulmonary fibrosis, and TIMP expression there exceeds that of MMP [12].
Negative_regulation (exceeds) of Gene_expression (expression) of TIMP in lungs associated with fibrosis and pulmonary fibrosis
2) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.69 Pain Relevance 0.28
Determination of IL-6, TIMP-1 and pro-MMP9 levels in BAL
Negative_regulation (Determination) of Gene_expression (levels) of TIMP
3) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0 Pain Relevance 0.03
However, EPA administration reduced the phosphorylation of NF-?
Negative_regulation (reduced) of Gene_expression (administration) of EPA
4) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.73 Pain Relevance 0.13
In the present study, we measured the expression of MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9, in the sera and culture supernatants of dermal fibroblasts from SSc patients and compared them with serum concentrations of transforming growth factor ?
Negative_regulation (inhibitor) of Gene_expression (expression) of TIMP in fibroblasts associated with metalloproteinase and systemic sclerosis
5) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.41 Pain Relevance 0.41
ELISA for matrix metalloproteinases (MMP) and tissue inhibitor of MMP (TIMP)
Negative_regulation (inhibitor) of Gene_expression (ELISA) of TIMP associated with metalloproteinase
6) Confidence 0.11 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.06 Pain Relevance 0.45
In addition, the level of tissue inhibitor of MMP-1 (TIMP-1), a natural protein inhibitor produced by chondrocytes, also remained stable (data not shown).
Negative_regulation (inhibitor) of Gene_expression (produced) of TIMP-1 in chondrocytes associated with metalloproteinase
7) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.32 Pain Relevance 0.24
HMW-HA decreased TIMP-1 expression in isolated human synovial fibroblasts [63], and hence may allow increased MMP activity, normalizing collagen turnover and thus preventing the fibrosis.
Negative_regulation (decreased) of Gene_expression (expression) of TIMP-1 in fibroblasts associated with fibrosis
8) Confidence 0.06 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.94 Pain Relevance 0.62

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