INT15846

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Context Info
Confidence 0.07
First Reported 1991
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.42
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, ENG) extracellular space (Crh, ENG) response to stress (Crh)
extracellular region (Crh) nucleolus (ENG) cell adhesion (ENG)
Crh (Rattus norvegicus)
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 17 99.92 Very High Very High Very High
noradrenaline 10 98.60 Very High Very High Very High
Opioid 129 94.48 High High
cytokine 7 86.84 High High
antagonist 11 82.56 Quite High
Inflammatory response 1 81.04 Quite High
Inflammation 65 78.00 Quite High
analgesia 56 75.32 Quite High
Endogenous opioid 37 73.32 Quite High
antinociception 37 67.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 81.04 Quite High
Stress 18 74.64 Quite High
Pain 37 50.00 Quite Low
Nociception 9 46.68 Quite Low
Adhesions 13 5.00 Very Low Very Low Very Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Inflammatory Pain 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent in vitro studies have shown that the release of hypothalamic beta-endorphin (beta-END), like that of adenohypophysial origin, is enhanced by both corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP).
corticotropin-releasing hormone Positive_regulation (enhanced) of Localization (release) of beta-END
1) Confidence 0.07 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0
Recent in vitro studies have shown that the release of hypothalamic beta-endorphin (beta-END), like that of adenohypophysial origin, is enhanced by both corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP).
CRH Positive_regulation (enhanced) of Localization (release) of beta-END
2) Confidence 0.07 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0
CRF induces the release of END, ENK, and DYN (Cabot et al 2001); noradrenaline releases END (Binder et al 2004; Mousa et al 2004); and IL-1?
CRF Positive_regulation (induces) of Localization (release) of END associated with noradrenaline and enkephalin
3) Confidence 0.02 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.42 Pain Relevance 1.38

General Comments

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