INT158469

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.76
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (FECH) mitochondrion (FECH) small molecule metabolic process (FECH)
FECH (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 125 99.80 Very High Very High Very High
Chronic low back pain 1 71.64 Quite High
Calcium channel 2 71.52 Quite High
Pain score 1 31.44 Quite Low
Sciatic nerve 1 8.00 Low Low
tetrodotoxin 1 6.76 Low Low
Action potential 11 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erythropoietic Protoporphyria 8 100.00 Very High Very High Very High
Pain 109 99.80 Very High Very High Very High
Sunburn 1 96.40 Very High Very High Very High
Low Back Pain 19 71.64 Quite High
Porphyria 1 71.44 Quite High
Anaemia 1 55.20 Quite High
Thrombocytopenia 1 54.32 Quite High
Myalgia 2 32.76 Quite Low
Myasthenia Gravis 1 32.08 Quite Low
Injury 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A total of 162 subjects (82%) reported a pain response following the FCE. 53 subjects reported pain prior to the FCE and 57 subjects reported pain directly after the FCE.
Regulation (following) of FCE associated with pain
1) Confidence 0.36 Published 2008 Journal J Occup Rehabil Section Body Doc Link PMC2522381 Disease Relevance 0.99 Pain Relevance 0.99
Partial deficiency of the last enzyme of the heme biosynthetic pathway (namely ferrochelatase, FECH) in humans is responsible for erythropoietic protoporphyria (EPP).
Regulation (responsible) of EPP associated with erythropoietic protoporphyria
2) Confidence 0.11 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268001 Disease Relevance 0.77 Pain Relevance 0.10
The nature of these changes in EPP time course is likely to be multifactorial.
Regulation (changes) of EPP
3) Confidence 0.02 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0 Pain Relevance 0.04

General Comments

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