INT158485

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 1.40
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm6) plasma membrane (Grm6) signal transducer activity (Grm6)
Anatomy Link Frequency
row 2
ganglion cell layer 2
glial cells 1
photoreceptor cells 1
rod bipolar cell 1
Grm6 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 16 100.00 Very High Very High Very High
gABA 10 95.52 Very High Very High Very High
Kinase C 20 86.00 High High
member 8 20 32.96 Quite Low
Calcium channel 1 25.00 Low Low
Glutamate 12 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
dorsal root ganglion 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 140 97.94 Very High Very High Very High
Night Blindness 89 97.68 Very High Very High Very High
Targeted Disruption 31 75.60 Quite High
Refractive Errors 4 65.68 Quite High
Myopia 16 64.96 Quite High
Apoptosis 10 45.68 Quite Low
Adhesions 30 41.40 Quite Low
Death 30 37.92 Quite Low
Retina Disease 10 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This set included genes previously shown to be expressed in bipolar cells, such as metabotropic glutamate receptor 6 (Grm6; Nakajima et al., 1993; Vardi and Morigiwa, 1997), ?
Gene_expression (expressed) of Grm6 associated with glutamate receptor
1) Confidence 0.71 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0.10
Scgn-positive cells were both Grm6 positive and Grm6 negative (Fig. 3H; Table 3; Scgn row; column j), suggesting that Scgn is expressed in both ON and OFF cone bipolar cells.
Gene_expression (positive) of Grm6 in row
2) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
Trpm1-positive cells were almost all labeled with the Chx10 probe, but only a minority of cells was positive for Pcp2 or Grm6, suggesting that Trpm1 is expressed in cone OFF bipolar cells and in a small number of cone ON bipolar cells and rod bipolar cells. 6330514A18Rik is expressed in bipolar cells and photoreceptor cells, and from the double-labeling experiments, it was found in a small minority of Pcp2-positive cells and in at least some Grm6-positive cells.
Gene_expression (expressed) of Grm6 in photoreceptor cells
3) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.16 Pain Relevance 0
This set included genes previously shown to be expressed in bipolar cells, such as metabotropic glutamate receptor 6 (Grm6; Nakajima et al., 1993; Vardi and Morigiwa, 1997), ?
Gene_expression (al.) of Grm6 associated with glutamate receptor
4) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0.10
The percentages of Og9x-positive cells that were also positive for Pcp2, Grm6, and Chx10 were 69.8%, 83.7%, and 98.8%, respectively (Table 3; Og9x row; columns i, j, k).
Gene_expression (positive) of Grm6 in row
5) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
Nfasc is expressed in bipolar cells and the amacrine and the ganglion cell layer, and it was detected in dissociated cells in at least some Pcp2-positive cells and a small fraction of Grm6-positive cells.
Gene_expression (fraction) of Grm6 in ganglion cell layer associated with ganglion cysts
6) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.19 Pain Relevance 0
Because Chx10 is also expressed in a subset of Müller glial cells (Liu et al., 1994; Burmeister et al., 1996; Rowan and Cepko, 2004), the estimate of the fraction of bipolar cells out of the total population using Chx10 is likely slightly overestimated, and the estimate of ON bipolar cells using Grm6 and Chx10 is likely underestimated.
Gene_expression (using) of Grm6 in glial cells
7) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0.04
The majority of Car8-positive cells were also positive for Pcp2, Grm6, and Chx10, suggesting that Car8 is a rod bipolar cell-specific gene. 2300002D11Rik is expressed in bipolar cells and the ganglion cell layer, and from the double-labeling studies, it was observed in at least some Pcp2-positive cells and Grm6-positive cells.
Gene_expression (positive) of Grm6 in ganglion cell layer associated with ganglion cysts
8) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.17 Pain Relevance 0
This set included genes previously shown to be expressed in bipolar cells, such as metabotropic glutamate receptor 6 (Grm6; Nakajima et al., 1993; Vardi and Morigiwa, 1997), ?
Gene_expression (metabotropic) of Grm6 associated with glutamate receptor
9) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0.10
Probes for novel bipolar cell-enriched markers were labeled with a red fluorophore, and co-expression with a rod bipolar cell-enriched gene, Pcp2 (Berrebi et al., 1991), an ON bipolar cell-specific gene, Grm6 (Nakajima et al., 1993; Vardi and Morigiwa, 1997), or a pan-bipolar cell gene, Chx10 (Liu et al., 1994; Burmeister et al., 1996), each labeled by a green fluorescent probe, was assessed.
Gene_expression (expression) of Grm6 in rod bipolar cell
10) Confidence 0.55 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
mGluR6 expression is a characteristic property of retinal ON bipolar cells. mGluR6 is also the causal gene for a form of congenital night blindness.
Gene_expression (expression) of mGluR6 associated with night blindness
11) Confidence 0.33 Published 2009 Journal J. Biochem. Section Abstract Doc Link 19270057 Disease Relevance 0.17 Pain Relevance 0
-actin gene (CAG) promoter region in CAG-TRPM1 was replaced with the 9.5 kb fragment of mGluR6 5?
Gene_expression (replaced) of mGluR6
12) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
We previously identified NYX mutations in five families and GRM6 mutations in two families among 11 Japanese families with complete CSNB [43,44], and in the current study, we found TRPM1 mutations in three of the remaining four families.
Gene_expression (mutations) of GRM6 associated with night blindness
13) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.72 Pain Relevance 0

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