INT158486

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.49
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sema3a) extracellular region (Sema3a)
Anatomy Link Frequency
nerve 2
medial 2
sympathetic 2
Sema3a (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 59 92.56 High High
diabetic neuropathy 1 85.76 High High
ischemia 3 79.68 Quite High
Pain 3 76.20 Quite High
dorsal root ganglion 37 71.28 Quite High
nociceptor 3 64.32 Quite High
Inflammation 7 57.20 Quite High
bDMF 49 46.12 Quite Low
vanilloid receptor subtype 1 1 42.64 Quite Low
qutenza 3 39.36 Quite Low
Disease Link Frequency Relevance Heat
Eczema 108 99.28 Very High Very High Very High
Pruritus 24 94.28 High High
Recurrence 1 87.40 High High
Diabetic Neuropathy 1 85.76 High High
Coronary Artery Disease 3 80.56 Quite High
Diabetes Mellitus 3 80.52 Quite High
Ganglion Cysts 82 80.36 Quite High
Myocardial Infarction 2 79.68 Quite High
Pain 2 76.20 Quite High
Heart Disease 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By comparison, the neural chemorepellent Sema3a is expressed at high levels in the subendocardium in the early stage of embryogenesis and is downregulated as development progresses, leading to epicardial-to-endocardial transmural sympathetic innervation patterning.
Negative_regulation (downregulated) of Gene_expression (expressed) of Sema3a in sympathetic
1) Confidence 0.41 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19270423 Disease Relevance 1.00 Pain Relevance 0.41
Sema3A expression decreases from the medial to lateral tongue surface and prevents premature and aberrant growth of trigeminal and gustatory fibers into the tongue mid-region.
Negative_regulation (decreases) of Gene_expression (expression) of Sema3A in medial
2) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.14 Pain Relevance 0
Recently, there has been an interesting report that epidermal Sema3A levels were decreased in patients with AD compared with healthy volunteers, concomitant with the increase of epidermal nerve densities.35 This result shows that there is a good correlation between epidermal innervation and Sema3A levels, which may provide an important evidence for the therapeutic claim against itching.
Negative_regulation (decreased) of Gene_expression (levels) of Sema3A in nerve associated with pruritus and eczema
3) Confidence 0.33 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 1.15 Pain Relevance 0.03
A statistically significant defect in the Sema3A response of Fps-deficient DRGs was also detected, but only under conditions were NGF was depleted prior to addition of Sema3A (Figure 7F).
Negative_regulation (depleted) of Gene_expression (addition) of Sema3A
4) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.20 Pain Relevance 0.13

General Comments

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