INT15850

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 5.64
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trim25) nucleus (Trim25) molecular_function (Trim25)
cellular_component (Trim25) cytoplasm (Trim25)
Anatomy Link Frequency
blood 1
nerve 1
DRG 1
Trim25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 13 100.00 Very High Very High Very High
Neuritis 8 99.72 Very High Very High Very High
dorsal root ganglion 30 99.24 Very High Very High Very High
Demyelination 1 97.84 Very High Very High Very High
ischemia 3 97.60 Very High Very High Very High
backache 3 85.68 High High
Sciatica 3 84.56 Quite High
Sciatic nerve 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 19 100.00 Very High Very High Very High
INFLAMMATION 13 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 8 99.72 Very High Very High Very High
Injury 3 99.70 Very High Very High Very High
Ganglion Cysts 30 99.24 Very High Very High Very High
Demyelinating Disease 1 97.84 Very High Very High Very High
Cv Unclassified Under Development 3 97.60 Very High Very High Very High
Wallerian Degeneration 1 94.12 High High
Disease 1 79.00 Quite High
Nerve Root Compression 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An acute compression to the nerve root increased endoneurial edema, increased EFP in the associated DRG, and reduced DRG blood flow.
Positive_regulation (increased) of EFP in DRG associated with dorsal root ganglion and pressure and volume under development
1) Confidence 0.43 Published 2005 Journal J. Orthop. Res. Section Abstract Doc Link 15734257 Disease Relevance 1.17 Pain Relevance 0.59
The objective of the current study was to test the hypothesis that crush injury to nerve root increases endoneurial fluid pressure (EFP) and decreases blood flow in the associated dorsal root ganglion (DRG).
Positive_regulation (increases) of EFP in nerve associated with ganglion cysts, dorsal root ganglion and injury
2) Confidence 0.38 Published 2005 Journal J. Orthop. Res. Section Abstract Doc Link 15734257 Disease Relevance 0.65 Pain Relevance 0.24
This combination of increased EFP and decreased blood flow in the DRG may result in neuronal ischemia and sensory dysfunction.
Positive_regulation (increased) of EFP in blood associated with dorsal root ganglion and ischemia
3) Confidence 0.38 Published 2005 Journal J. Orthop. Res. Section Abstract Doc Link 15734257 Disease Relevance 1.11 Pain Relevance 0.60
These findings suggest suggest that altered vascular permeability is the earliest morphologic change in experimental allergic neuritis, followed by accumulation of antibody-containing edema fluid, penetration of the endoneurium by inflammatory cells, and increased EFP.
Positive_regulation (accumulation) of EFP associated with pressure and volume under development, inflammation, experimental autoimmune neuritis and neuritis
4) Confidence 0.36 Published 1983 Journal Lab. Invest. Section Abstract Doc Link 6338293 Disease Relevance 0.86 Pain Relevance 0.38
These findings suggest suggest that altered vascular permeability is the earliest morphologic change in experimental allergic neuritis, followed by accumulation of antibody-containing edema fluid, penetration of the endoneurium by inflammatory cells, and increased EFP.
Positive_regulation (increased) of EFP associated with pressure and volume under development, inflammation, experimental autoimmune neuritis and neuritis
5) Confidence 0.36 Published 1983 Journal Lab. Invest. Section Abstract Doc Link 6338293 Disease Relevance 0.83 Pain Relevance 0.37
Axonal damage appeared at the height of the inflammatory process, when edema and increased EFP were maximal.
Positive_regulation (increased) of EFP associated with pressure and volume under development and inflammation
6) Confidence 0.28 Published 1991 Journal Acta Neuropathol. Section Abstract Doc Link 1767630 Disease Relevance 1.02 Pain Relevance 0.36

General Comments

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