INT15852

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Context Info
Confidence 0.40
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.60
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
30/15 1
Epithelial cells 1
suture 1
inferior 1
PSS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 99.92 Very High Very High Very High
spastic colon 19 93.20 High High
Kinase C 2 91.44 High High
palliative 1 91.20 High High
Analgesic 2 84.28 Quite High
anesthesia 4 76.40 Quite High
ketamine 1 75.96 Quite High
cytokine 2 70.24 Quite High
psoriasis 1 66.48 Quite High
adenocard 2 36.64 Quite Low
Disease Link Frequency Relevance Heat
Celiac Disease 24 100.00 Very High Very High Very High
Orthostatic Intolerance /

Orthostatic Intolerance

2 100.00 Very High Very High Very High
Mucositis 2 99.92 Very High Very High Very High
Disease 10 99.46 Very High Very High Very High
Cancer 18 99.34 Very High Very High Very High
Myeloid Metaplasia 4 98.66 Very High Very High Very High
Thrombocytopenia 5 98.52 Very High Very High Very High
Weight Gain 2 98.24 Very High Very High Very High
Food Hypersensitivity 5 95.76 Very High Very High Very High
Frailty 2 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that presplenectomy thrombocytopenia in MMM may be a surrogate for advanced disease and is associated with an increased risk of BT and inferior PSS.
Positive_regulation (increased) of PSS in inferior associated with thrombocytopenia, disease and myeloid metaplasia
1) Confidence 0.40 Published 2000 Journal Blood Section Abstract Doc Link 10733489 Disease Relevance 1.04 Pain Relevance 0.09
SBP and standing RR 30/15 ratio between pSS patients and control individuals are consistent with some orthostatic intolerance in pSS, also observed in the COMPASS subscale scores (Table 2), the magnitude of these differences is relatively modest and the values are within the normal range [16].
Positive_regulation (intolerance) of pSS in 30/15
2) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453776 Disease Relevance 0.41 Pain Relevance 0
It thus appears likely that SRPK1-mediated phosphorylation of ASF/SF2 could support an activation of the PSS and increased production of pro-angiogenic isoforms.
Positive_regulation (activation) of PSS
3) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.13 Pain Relevance 0
Epithelial cells treated with insulin-like growth factor-1 (IGF-1) increased PSS and produced more VEGF165 and less VEGF165b.
Positive_regulation (increased) of PSS in Epithelial cells
4) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0.06 Pain Relevance 0.05
The pathways by which mucosal inflammation is induced by rectal challenge with gluten and CM in CD or pSS have not been identified until now.
Positive_regulation (induced) of pSS associated with celiac disease, mucositis and inflammation
5) Confidence 0.07 Published 2008 Journal Clinical and Experimental Allergy Section Body Doc Link PMC2440347 Disease Relevance 1.24 Pain Relevance 0.18
Portal vein inflow, PSS, NH3 delivery, and CSF glutamine were significantly increased in both PCA-suture and PCA-glue animals compared with sham rats, although no significant differences were seen between the two PCA techniques.
Positive_regulation (increased) of PSS in suture
6) Confidence 0.05 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1767849 Disease Relevance 0.28 Pain Relevance 0.11
Among them, glucosyldiacylglycerol has been reported to have a few biological effects, including significant fibrinolysis [13, 14], specific inhibition of tumor [15], and increased the cloning activation of phosphatidylserine decarboxylase in both the Bacillus subtilis null pss and psd mutants [16].
Positive_regulation (activation) of pss associated with cancer
7) Confidence 0.03 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707035 Disease Relevance 0.71 Pain Relevance 0.16
In another series of experiments, LPS increased the mortality rate compared with the vehicle group (i.v. drip of PSS at a rate of 0.3 mL/h) during a 6 h observation period.
Positive_regulation (increased) of PSS
8) Confidence 0.02 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16445696 Disease Relevance 0.54 Pain Relevance 0.07

General Comments

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