INT158545

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Context Info
Confidence 0.55
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 8
Disease Relevance 0
Pain Relevance 1.24

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transport (Trpc3) endoplasmic reticulum (Jph2) plasma membrane (Jph2)
Anatomy Link Frequency
skeletal muscle 3
covering 2
myotubes 2
Trpc3 (Mus musculus)
Jph2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 16 99.24 Very High Very High Very High
member 8 8 87.92 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through mutational studies, we found that the binding ability of JP2 to TRPC3 was mainly due to glutamate in the F1-2 region (E227).
TRPC3 Binding (binding) of JP2 associated with glutamate
1) Confidence 0.55 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.16
A region covering 143 to 234 amino acids of JP2 (F1-2) was the most efficient portion binding to TRPC3.
TRPC3 Binding (binding) of JP2 in covering
2) Confidence 0.55 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.16
A region covering 143 to 234 amino acids of JP2 (F1-2) was the most efficient portion binding to TRPC3.
TRPC3 Binding (binding) of F1-2 in covering
3) Confidence 0.41 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.16
Based on these knowledge from bona-fide TRPC3-expressing cells, to identify critical binding region(s) of JP2 that participate in binding to TRPC3, various JP2 portions were subjected to co-immunoprecipitation assay with intact TRPC3 from rabbit skeletal muscle.
TRPC3 Binding (binding) of JP2 in skeletal muscle
4) Confidence 0.41 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.16
This substantial binding between JP2 and TRPC3 suggests that JP2 can be a regulatory protein of TRPC3 and/or TRPC3-mediated Ca(2+) homeostasis in skeletal muscle.
TRPC3 Binding (binding) of JP2 in skeletal muscle
5) Confidence 0.41 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.15
Junctophilin-2 (JP2) is a TRPC3-interacting protein in mouse skeletal myotubes.
TRPC3 Binding (interacting) of Junctophilin-2 in myotubes
6) Confidence 0.41 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.16
Junctophilin-2 (JP2) is a TRPC3-interacting protein in mouse skeletal myotubes.
TRPC3 Binding (interacting) of JP2 in myotubes
7) Confidence 0.41 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.15
Based on these knowledge from bona-fide TRPC3-expressing cells, to identify critical binding region(s) of JP2 that participate in binding to TRPC3, various JP2 portions were subjected to co-immunoprecipitation assay with intact TRPC3 from rabbit skeletal muscle.
TRPC3 Binding (binding) of JP2 in skeletal muscle
8) Confidence 0.36 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.15

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