INT158547

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
dorsal root ganglion 2
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Taxol 60 99.98 Very High Very High Very High
dorsal root ganglion 36 99.04 Very High Very High Very High
Calcium channel 1 96.20 Very High Very High Very High
Pain 28 91.08 High High
imagery 24 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Hyperalgesia 8 5.00 Very Low Very Low Very Low
Mechanosensation 6 5.00 Very Low Very Low Very Low
Mechanotransduction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 36 98.56 Very High Very High Very High
Nociception 29 94.16 High High
Pain 26 91.08 High High
Neuropathic Pain 10 5.00 Very Low Very Low Very Low
Hyperalgesia 8 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stabilization of microtubules by Taxol reduces Ca2+-influx through TRPV4 activation
Negative_regulation (reduces) of Positive_regulation (activation) of TRPV4 associated with taxol
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.12
Inhibition of the expression and function of TRPV4 by RNA interference in dorsal root ganglion.
Negative_regulation (Inhibition) of Positive_regulation (function) of TRPV4 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.43 Published 2010 Journal Neurol. Res. Section Title Doc Link 19278577 Disease Relevance 0.47 Pain Relevance 0.41
We observed that the normalized average Ca2+-influx due to TRPV4 activation was strongly diminished (but not abolished) if the cells were treated with Taxol (Fig. 6a).
Neg (not) Negative_regulation (diminished) of Positive_regulation (activation) of TRPV4 associated with taxol
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.24

General Comments

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