INT158548

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.03
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
neurons 2
oral mucosa 2
DRG 2
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 24 100.00 Very High Very High Very High
Pain 19 98.80 Very High Very High Very High
Calcium channel 2 91.68 High High
Serotonin 1 78.88 Quite High
5HT 4 78.00 Quite High
nociceptor 4 38.64 Quite Low
agonist 6 33.44 Quite Low
Taxol 30 29.52 Quite Low
Hyperalgesia 6 25.00 Low Low
imagery 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 24 100.00 Very High Very High Very High
Pain 18 98.80 Very High Very High Very High
Nociception 20 93.56 High High
Hyperalgesia 6 25.00 Low Low
Neuropathic Pain 5 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study intended to evaluate the effect of small interfering RNA (siRNA) on the expression and function of TRPV4 in DRG neurons and its possible usage in pain relief treatment.
Spec (possible) Regulation (effect) of Gene_expression (expression) of TRPV4 in neurons associated with pain and dorsal root ganglion
1) Confidence 0.61 Published 2010 Journal Neurol. Res. Section Abstract Doc Link 19278577 Disease Relevance 0.65 Pain Relevance 0.42
Real-time reverse transcription polymerase chain reaction and Western blot analysis were performed to assess the change of TRPV4 messenger RNA (mRNA) and protein expression in DRG.
Regulation (change) of Gene_expression (expression) of TRPV4 in DRG
2) Confidence 0.45 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.17 Pain Relevance 0
We studied the function of TRPV4 expression and its neuronal activation in response to noxious stimulation of oral mucosa.
Regulation (function) of Gene_expression (expression) of TRPV4 in oral mucosa
3) Confidence 0.27 Published 2009 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 19877445 Disease Relevance 0.21 Pain Relevance 0.15
All these results confirm that activation of TRPV4 results in microtubules disassembly and this effect is independent of TRPV4 expression level in whatever cellular context chosen.


Neg (independent) Regulation (independent) of Gene_expression (expression) of TRPV4
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0

General Comments

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