INT158565

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 3.93
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Anatomy Link Frequency
PSC 2
lung 1
Ctgf (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 167 99.16 Very High Very High Very High
Chronic pancreatitis 9 98.68 Very High Very High Very High
alcohol 4 94.52 High High
Inflammatory response 5 63.04 Quite High
Inflammatory marker 5 57.48 Quite High
Inflammation 46 50.08 Quite High
chemokine 5 20.88 Low Low
corticosteroid 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 12 99.84 Very High Very High Very High
Fibrosis 269 99.64 Very High Very High Very High
Pancreatitis 10 98.68 Very High Very High Very High
Disease 41 95.68 Very High Very High Very High
Sprains And Strains 5 87.20 High High
Targeted Disruption 30 74.88 Quite High
INFLAMMATION 56 62.68 Quite High
Keloid Scars 11 46.44 Quite Low
Necrosis 1 45.32 Quite Low
Stress 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In view of the central role of connective tissue growth factor (CCN2) in fibrosis, we investigated the mechanisms by which CCN2 is regulated in PSC following their exposure to ethanol or acetaldehyde.
Regulation (regulated) of CCN2 in PSC associated with fibrosis and primary sclerosing cholangitis
1) Confidence 0.61 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.56 Pain Relevance 0.28
Although down-regulation of CTGF has been employed in treating fibrotic conditions [28], application of SPARC inhibition in attenuation of a fibrotic process in a therapeutic animal model has not been reported.
Regulation (regulation) of CTGF associated with fibrosis
2) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.49 Pain Relevance 0.05
We used Ctgf siRNA as a positive control for inhibition of Ctgf and collagen expression.
Regulation (control) of Ctgf siRNA
3) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
Bleomycin injection induced an up-regulation of the Col1a2, Col3a1, Ctgf and SPARC gene in both skin (Figure 5A, P = 0.028, 0.016, 0.049 and 0.0005, respectively) and lung tissues (Figure 5B, P = 0.015, 0.005, 0.041 and 0.056, respectively) of the mice significantly or marginal significantly.
Regulation (regulation) of Ctgf in lung
4) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
PSC-derived CTGF is thus a candidate therapeutic target in anti-fibrotic strategies for ACP.
Regulation (target) of CTGF in PSC associated with fibrosis, primary sclerosing cholangitis and chronic pancreatitis
5) Confidence 0.25 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.23 Pain Relevance 0.56
Notably, these changes were accompanied with a significant down regulation of Ctgf that paralleled with Ctgf up-regulation in bleomycin-induced tissues.
Regulation (regulation) of Ctgf
6) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.77 Pain Relevance 0.15
Notably, these changes were accompanied with a significant down regulation of Ctgf that paralleled with Ctgf up-regulation in bleomycin-induced tissues.
Regulation (regulation) of Ctgf
7) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.67 Pain Relevance 0.10

General Comments

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