INT158566

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp24a1) oxidoreductase activity (Cyp24a1)
Anatomy Link Frequency
PSC 1
Cyp24a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 71.20 Quite High
alcohol 2 66.84 Quite High
fibrosis 2 54.84 Quite High
Chronic pancreatitis 1 49.32 Quite Low
carbamazepine 1 6.44 Low Low
Bile 39 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 7 95.70 Very High Very High Very High
Stress 2 94.88 High High
Targeted Disruption 17 75.36 Quite High
Rickets 8 62.88 Quite High
Fibrosis 2 54.84 Quite High
Pancreatitis 1 49.32 Quite Low
Metabolic Bone Disease 1 9.72 Low Low
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was later shown that activation of SXR did not induce CYP24 expression in vitro or in vivo, nor did it transactivate the CYP24 promoter [Zhou et al., 2006a].
Neg (nor) Positive_regulation (transactivate) of CYP24
1) Confidence 0.27 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.04
Accumulation of reactive oxygen species in PSC after exposure to ethanol was verified by loading the cells with dichlorofluorescin diacetate and showing that there was a stimulation of its oxidized fluorescent product, the latter of which was diminished in the presence of catalase or vitamin D.
Positive_regulation (presence) of vitamin D in PSC associated with primary sclerosing cholangitis
2) Confidence 0.06 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.55 Pain Relevance 0.09

General Comments

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