INT158577

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.36
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
lung 4
eyes 2
astrocytes 2
Plg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 124 100.00 Very High Very High Very High
Central nervous system 9 90.84 High High
ischemia 6 74.72 Quite High
halothane 4 45.44 Quite Low
anesthesia 6 44.64 Quite Low
aspirin 4 30.40 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 127 100.00 Very High Very High Very High
Diabetes Mellitus 72 99.62 Very High Very High Very High
Asthma 164 99.48 Very High Very High Very High
Occupational Lung Diseases 12 90.72 High High
Targeted Disruption 12 87.44 High High
Cv Unclassified Under Development 5 74.72 Quite High
Stroke 27 64.44 Quite High
Cicatrix 4 63.52 Quite High
Disease 13 57.24 Quite High
Thyroid Neoplasm 5 50.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then assessed the impact of COX-2 down-regulation on airway inflammation, lung function, and PG production.


Negative_regulation (regulation) of Gene_expression (production) of PG in lung associated with inflammation
1) Confidence 0.17 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.70 Pain Relevance 0.08
We then assessed the impact of COX-2 down-regulation on airway inflammation, lung function, and PG production.


Negative_regulation (down) of Gene_expression (production) of PG in lung associated with inflammation
2) Confidence 0.17 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.70 Pain Relevance 0.08
Rather than induce complete inhibition of COX-2 production or impair its activity, the inhibitory strategy used in our experiment was intended to mimic the described reduced production of COX-2 [5-7] and hence PG [4,8,39] in asthma.
Negative_regulation (mimic) of Gene_expression (production) of PG associated with asthma
3) Confidence 0.17 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.35 Pain Relevance 0.04
Rather than induce complete inhibition of COX-2 production or impair its activity, the inhibitory strategy used in our experiment was intended to mimic the described reduced production of COX-2 [5-7] and hence PG [4,8,39] in asthma.
Negative_regulation (reduced) of Gene_expression (production) of PG associated with asthma
4) Confidence 0.17 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.35 Pain Relevance 0.04
Retinal parenchyma fluorescence at 10 (Figure 3G) and 15 (Figure 3H) days after induction of diabetes in eyes with rAAV-angiostatin injection was decreased as compared with eyes that received the rAAV-lacZ injection.
Negative_regulation (decreased) of Gene_expression (injection) of angiostatin in eyes associated with diabetes mellitus
5) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.67 Pain Relevance 0
In brain, tissue plasminogen activator (tPA) expression in astrocytes is the primary source of plasminogen activator and PAI-1 is the dominant inhibitor of tPA [21].
Negative_regulation (inhibitor) of Gene_expression (source) of plasminogen in astrocytes
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.53 Pain Relevance 0.18
The expression of the constitutive PG synthesis enzyme, cyclooxygenase 1, was diminished, while the level of the catabolism enzyme, 15-PG dehydrogenase, was decreased.
Negative_regulation (diminished) of Gene_expression (expression) of PG synthesis enzyme
7) Confidence 0.01 Published 2009 Journal Thyroid Section Body Doc Link 19281427 Disease Relevance 0.05 Pain Relevance 0

General Comments

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