INT158595

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 12.09
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr3) signal transduction (Tlr3) endoplasmic reticulum (Tlr3)
RNA binding (Tlr3) intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
lungs 3
epithelial cells 2
Microglia 2
glial cells 2
neurons 2
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 363 100.00 Very High Very High Very High
Central nervous system 208 98.86 Very High Very High Very High
Inflammatory response 96 98.28 Very High Very High Very High
Chronic pancreatitis 3 97.00 Very High Very High Very High
chemokine 252 95.08 Very High Very High Very High
rheumatoid arthritis 187 93.72 High High
Inflammation 441 90.88 High High
tolerance 11 87.28 High High
Neurotransmitter 9 82.44 Quite High
Glutamate 32 81.20 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 16 98.88 Very High Very High Very High
Influenza Virus Infection 186 98.72 Very High Very High Very High
Neurodegenerative Disease 137 98.64 Very High Very High Very High
Viral Infection 139 98.52 Very High Very High Very High
Infection 142 98.32 Very High Very High Very High
INFLAMMATION 484 97.88 Very High Very High Very High
Rabies Virus Infection 12 97.52 Very High Very High Very High
Pancreatitis 4 97.00 Very High Very High Very High
Neuroblastoma 1 95.20 Very High Very High Very High
Bacterial Infection 19 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although we did not specifically measure TLR3 expression in the current study, review of our previously published microarray study indicates that TLR4 mRNA but not TLR3 mRNA is increased in mice mechanically ventilated with a tidal volume of 10 mL/kg as compared with control mice [9].
Gene_expression (expression) of TLR3
1) Confidence 0.69 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.31 Pain Relevance 0.09
Paraffin-embedded tissues from dsRNA-treated and ssRNA-treated lungs were processed for immunohistochemical localization of Toll-like receptor 3 (TLR3) expression using a method previously described [33,39].
Gene_expression (expression) of Toll-like receptor 3 in lungs
2) Confidence 0.69 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.09 Pain Relevance 0
Our study showed that dsRNA treatment induced the expression of TLR3 on the cell surface of airways as compared to ssRNA-treated controls animals.
Gene_expression (expression) of TLR3
3) Confidence 0.69 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.57 Pain Relevance 0.08
Paraffin-embedded tissues from dsRNA-treated and ssRNA-treated lungs were processed for immunohistochemical localization of Toll-like receptor 3 (TLR3) expression using a method previously described [33,39].
Gene_expression (expression) of TLR3 in lungs
4) Confidence 0.69 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.09 Pain Relevance 0
These findings indicate that TLR3 signaling generates the Fas/FasL-mediated cytotoxicity, thereby leading to the development of chronic pancreatitis.
Gene_expression (generates) of TLR3 associated with chronic pancreatitis
5) Confidence 0.66 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.29 Pain Relevance 0.27
However, an alternative strategy takes advantage of the fact that all of the TLRs, with the exception of TLR3, as well as many of the early response cytokine receptors utilize the adapter protein, myeloid differentiation factor 88 (MyD88) [25,26].
Neg (exception) Gene_expression (utilize) of TLR3 associated with cytokine
6) Confidence 0.60 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.34 Pain Relevance 0.22
To summarize the first set of experiments, mechanical ventilation amplified cytokine expression following TLR3 stimulation via MyD88-dependent pathway(s).
Gene_expression (expression) of TLR3 associated with cytokine
7) Confidence 0.54 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.07 Pain Relevance 0.16
The upregulation of TLR3 in dsRNA-exposed mouse airways suggests a positive feedback system in which epithelial cells exposed to dsRNA increase TLR3 expression on their cell surface.
Gene_expression (expression) of TLR3 in epithelial cells
8) Confidence 0.53 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.54 Pain Relevance 0.10
DsRNA induces expression of TLR3 on airway epithelial cells
Gene_expression (expression) of TLR3 in epithelial cells
9) Confidence 0.53 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.23 Pain Relevance 0.11
Immunolocalization using goat anti-murine TLR3 Ab showed markedly increased expression of TLR3 localized to the surface airway epithelium of dsRNA-treated lungs as compared to ssRNA-treated controls at 72 h.
Gene_expression (expression) of TLR3 in lungs
10) Confidence 0.53 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.26 Pain Relevance 0.08
The putative receptor for dsRNA has been identified as Toll-like receptor 3 (TLR3), thus we first determined whether dsRNA treatment was associated with expression of TLR3.
Gene_expression (expression) of TLR3
11) Confidence 0.53 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.27 Pain Relevance 0.09
Previous studies indicated that neurons express TLR2 [12,63] and TLR3 [45,64].
Gene_expression (express) of TLR3 in neurons
12) Confidence 0.52 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.39 Pain Relevance 0.40
TLR3 was found to be expressed in cultured human neurons following viral infection [60], and on neurons in human brain tissue in cases of rabies or herpes simplex virus infection [61].
Gene_expression (expressed) of TLR3 in neurons associated with cold sores, rabies virus infection and viral infection
13) Confidence 0.46 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.43 Pain Relevance 0.05
Most TLRs, except TLR3, that are expressed in different cells such as glial cells, signal via the founding family member of the MyD88 family, which predominantly activates an NF-?
Gene_expression (expressed) of TLR3 in glial cells
14) Confidence 0.46 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.44 Pain Relevance 0.03
However, with cultured astrocytes, TLR3 and TLR4 were found only on the cellular surface [26].
Gene_expression (found) of TLR3 in astrocytes
15) Confidence 0.46 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.38 Pain Relevance 0.32
Upon interaction with their ligands, TLRs signal through adapter proteins, most commonly Myeloid Differentiation Primary Response Gene 88 (MyD88), though TLR 3 alternatively signals via the TIR-Domain Containing Adaptor Inducing Interferon-?
Gene_expression (signals) of TLR 3
16) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.19 Pain Relevance 0.04
Under resting conditions, in rodents in vivo, TLRs 1–9 have been detected in the CNS by quantitative real-time PCR, with particularly strong expression of TLR3 [25].
Gene_expression (expression) of TLR3 associated with central nervous system
17) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.27 Pain Relevance 0.31
Furthermore, murine astrocyte seems to express under physiological condition high levels of TLR3 [46, 47].
Gene_expression (express) of TLR3 in astrocyte
18) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.59 Pain Relevance 0.38
Some TLRs are strongly expressed in the embryonic brain and TLR3 and TLR8 have been implicated in neurogenesis and neurite outgrowth in the developing brain whereas TLR2 and TLR4 have been shown to regulate adult neurogenesis [75, 76].
Gene_expression (expressed) of TLR3 in brain associated with neurodegenerative disease
19) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.59 Pain Relevance 0.06
Both TLR3 and TLR4 were found exclusively localized in vesicular structures inside microglia and not on the surface of the cells.
Neg (not) Gene_expression (found) of TLR3 in microglia
20) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.32 Pain Relevance 0.31

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