INT158596

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 11.66
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr3) signal transduction (Tlr3) endoplasmic reticulum (Tlr3)
RNA binding (Tlr3) intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
poly 4
intermediary 1
NK cell 1
epithelial cells 1
Astrocytes 1
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 59 100.00 Very High Very High Very High
Inflammation 415 99.00 Very High Very High Very High
cytokine 456 98.72 Very High Very High Very High
chemokine 70 97.92 Very High Very High Very High
agonist 166 95.42 Very High Very High Very High
Chronic pancreatitis 3 92.12 High High
Inflammatory stimuli 4 89.52 High High
Central nervous system 59 88.56 High High
antagonist 16 82.56 Quite High
adenocard 3 76.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 461 100.00 Very High Very High Very High
Hepatitis 27 99.74 Very High Very High Very High
Appetite Loss 4 99.72 Very High Very High Very High
Targeted Disruption 55 99.68 Very High Very High Very High
Necrosis 20 99.28 Very High Very High Very High
Togavirus Infection 35 98.96 Very High Very High Very High
Sprains And Strains 53 98.52 Very High Very High Very High
Hepatitis Virus Infection 2 98.52 Very High Very High Very High
Weight Loss 13 98.44 Very High Very High Very High
Influenza Virus Infection 303 98.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld).
TLR3 Binding (recognized) of in poly associated with sprains and strains
1) Confidence 0.47 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.44 Pain Relevance 0.17
As a dsRNA analogue, poly(I:C) is recognized by both TLR3 and MDA5 PRRs in vivo (Alexopoulou et al., 2001; Gitlin et al., 2006; Kato et al., 2006).
TLR3 Binding (recognized) of in poly
2) Confidence 0.33 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.12 Pain Relevance 0
Because noroviruses are RNA viruses, we investigated whether MDA5 and TLR3, cellular sensors that recognize dsRNA, are important for the host response to MNV-1.
TLR3 Binding (recognize) of
3) Confidence 0.33 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2443291 Disease Relevance 0.47 Pain Relevance 0.05
We hypothesized that mechanical ventilation with a tidal volume of 10 mL/kg generates endogenous ligands, either classical cytokines and/or damage-associated molecular patterns (DAMPs), which are recognized by MyD88-dependent transmembrane receptors, resulting in amplification of the inflammatory response from concurrently administered poly(I:C), a TLR3 ligand.
TLR3 Binding (recognized) of in poly associated with inflammatory response and cytokine
4) Confidence 0.32 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.76 Pain Relevance 0.41
Elimination of TLR3 in our knockout mice largely abrogates the adverse effects of poly(I ? 
TLR3 Binding (Elimination) of in poly associated with targeted disruption
5) Confidence 0.31 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.59 Pain Relevance 0.16
It has recently been shown that microglia respond to poly I:C [a synthetic double-stranded (ds) RNA analog thought to be recognized by TLR3, [39]] by producing pro-inflammatory cytokines and chemokines [40], and microglial pro-inflammatory responses to dsRNA seem to be dependent on TLR3, as TLR3-deficient microglia have blunted innate cytokine responses in vitro and markedly reduced cell surface activation markers in brain after poly I:C stimulation (Town et al., submitted).
TLR3 Binding (recognized) of in microglia associated with chemokine, inflammatory response, inflammation and cytokine
6) Confidence 0.31 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.88 Pain Relevance 0.69
As CHIKV is an ssRNA virus and likely replicates with a dsRNA intermediary, we predicted engagement of TLR7 and/or TLR3.
TLR3 Binding (engagement) of in intermediary
7) Confidence 0.29 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2822618 Disease Relevance 0.51 Pain Relevance 0.07
Similar to TLR2, TLR3 was also shown to recognize cells undergoing necrosis during acute inflammatory events, independently of viral infection [39].
TLR3 Binding (recognize) of associated with necrosis, inflammation and viral infection
8) Confidence 0.27 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.36 Pain Relevance 0.05
Double-stranded RNA produced during viral replication is recognized by an intracellular protein, TLR3, present in T, NK [15, 19, 20], mast [21] and epithelial cells [17].
TLR3 Binding (recognized) of in epithelial cells
9) Confidence 0.25 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.64 Pain Relevance 0.07
For example, cells infected by SFV, also a member of the Alphavirus genus, results in the generation of dsRNA that may engage TLR3 on CD8+ DCs upon engulfment (Schulz et al., 2005).
TLR3 Binding (engage) of associated with togavirus infection
10) Confidence 0.24 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2822618 Disease Relevance 0.34 Pain Relevance 0
Viral surface glycoproteins (e.g., the hemagglutinin protein of measles virus) have been reported as agonists for TLR2 and TLR4 (Kurt-Jones et al., 2000; Bieback et al., 2002; Rassa et al., 2002; Compton et al., 2003). ssRNA viruses (e.g., influenza) trigger TLR7 and TLR8 signaling (Diebold et al., 2004), whereas extracellular dsRNA is recognized by TLR3 (Alexopoulou et al., 2001), and unmethylated CpG-containing DNA viruses (e.g., herpes simplex virus) may activate TLR9 (Krug et al., 2004).
TLR3 Binding (recognized) of associated with herpes simplex virus, influenza virus infection, measles and agonist
11) Confidence 0.24 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2822618 Disease Relevance 0.36 Pain Relevance 0.09
With the exception of TLR3, ligand binding to TLRs stimulates recruitment of
TLR3 Neg (exception) Binding (exception) of
12) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.78 Pain Relevance 0.39
Unmethylated CpG dinucleotides present in bacterial DNA are recognized by TLR9 [11–13], single-stranded (ss)RNA viruses, such as vesicular stomatitis virus and influenza virus are recognized by TLR7 [14], and dsRNA longer than 30 base pairs, produced during the viral replicative cycle, is recognized by TLR3 [11, 13, 15, 16].
TLR3 Binding (recognized) of associated with influenza virus infection and vesicular stomatitis
13) Confidence 0.21 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.56 Pain Relevance 0.04
TLR3 recognizes double-stranded RNA (dsRNA).
TLR3 Binding (recognizes) of
14) Confidence 0.21 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.11 Pain Relevance 0.06
One structure shows that TLR3 interacts with hydrophilic double-stranded RNA (dsRNA) via surface-exposed sites [50].
TLR3 Binding (interacts) of
15) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.05 Pain Relevance 0
It has recently been demonstrated that TLR3 also binds polyriboinosinic acid, a ssRNA [34].
TLR3 Binding (binds) of
16) Confidence 0.18 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.11 Pain Relevance 0.07
Engagement of TLR3 resulted in powerful NK cell activation in KC-NK cell cocultures, but not when the two cells were separated in a Transwell tissue culture system [5].
TLR3 Binding (Engagement) of in NK cell
17) Confidence 0.18 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 0.19 Pain Relevance 0.07
Thus, dying cells release RNA, which can engage TLR3; nuclear DNA that can engage TLR9; and HMBG1 (high mobility group box protein 1) that can engage TLR4.
TLR3 Binding (engage) of
18) Confidence 0.16 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 0.79 Pain Relevance 0.19
Astrocytes and oligodendrocytes express mRNA for TLR2 that recognizes fungal, gram-positive and mycobacterial components and TLR3 that recognize double-stranded RNA.
TLR3 Binding (recognize) of in oligodendrocytes
19) Confidence 0.15 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.15 Pain Relevance 0.15
Components of hepatitis viruses are ligands for TLR3, TLR7, TLR8 and TLR9, but not for TLR4.
TLR3 Neg (not) Binding (ligands) of associated with hepatitis
20) Confidence 0.14 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.83 Pain Relevance 0.52

General Comments

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