INT1586

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.14
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 2
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 7 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
Opioid 4 99.40 Very High Very High Very High
opiate 5 99.00 Very High Very High Very High
Morphine 1 98.76 Very High Very High Very High
Enkephalin 8 98.20 Very High Very High Very High
dexamethasone 7 98.20 Very High Very High Very High
anesthesia 4 97.88 Very High Very High Very High
epidural 2 96.76 Very High Very High Very High
antagonist 2 95.00 High High
Disease Link Frequency Relevance Heat
Adrenal Cancer 137 97.76 Very High Very High Very High
Small Cell Lung Carcinoma 2 90.64 High High
Polycystic Ovary Syndrome 14 73.40 Quite High
Cancer 3 62.16 Quite High
Adrenal Insufficiency 3 59.68 Quite High
Reprotox - General 1 8 59.04 Quite High
Anxiety Disorder 1 52.20 Quite High
Hyperandrogenism 3 27.52 Quite Low
Obesity 3 19.20 Low Low
Hirsutism 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the effects of various cations on the binding of 125I-[D-Ala2]beta-endorphin are markedly different from those found for enkephalin binding.
Regulation (effects) of beta-endorphin Binding (binding) of associated with enkephalin
1) Confidence 0.45 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 217869 Disease Relevance 0 Pain Relevance 0.86
For effects on TPI formation both the sequences ACTH5-7 and ACTH10-16 were needed.
Regulation (effects) of ACTH Binding (formation) of
2) Confidence 0.44 Published 1981 Journal Brain Res. Section Abstract Doc Link 6269709 Disease Relevance 0 Pain Relevance 0.06
Correlation of hormone concentrations with genetic analyses has suggested that mutations are likely to be identified on both alleles when the ACTH-stimulated 17-OHP value exceeds 1500?
Regulation (exceeds) of ACTH-stimulated Spec (likely) Binding (value) of
3) Confidence 0.29 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.91 Pain Relevance 0.03
The beta-endorphin binding did not affect the production of cAMP, but was enhanced by dexamethasone pretreatment.
Neg (not) Regulation (affect) of beta-endorphin Binding (binding) of associated with dexamethasone
4) Confidence 0.29 Published 1995 Journal Exp. Cell Res. Section Abstract Doc Link 7641799 Disease Relevance 0.17 Pain Relevance 0.53
Influence on memory of posttraining or pre-test injections of ACTH, vasopressin, epinephrine, and beta-endorphin, and their interaction with naloxone.
Regulation (Influence) of beta-endorphin Binding (interaction) of associated with narcan
5) Confidence 0.27 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 2994140 Disease Relevance 0 Pain Relevance 0.31
Using in vitro cellular expression assays, this variant has been reported to change binding of the endogenous agonist beta-endorphin and signaling of the receptor following binding of beta-endorphin.
Regulation (change) of beta-endorphin Binding (binding) of associated with agonist
6) Confidence 0.27 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17877633 Disease Relevance 0.06 Pain Relevance 0.34
[Comparison of changes in plasma concentrations of ACTH and beta-endorphin in cholecystectomy under general anesthesia and general plus epidural anesthesia].
Regulation (changes) of ACTH Binding (concentrations) of in plasma associated with anesthesia and epidural
7) Confidence 0.12 Published 1995 Journal Rev Esp Anestesiol Reanim Section Title Doc Link 8584772 Disease Relevance 0 Pain Relevance 0.47

General Comments

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