INT158602

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.46
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX4) transport (P2RX4) plasma membrane (P2RX4)
response to stress (P2RX4)
Anatomy Link Frequency
macrophages 1
nerve 1
alveolar macrophages 1
dorsal horn 1
P2RX4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn 24 99.04 Very High Very High Very High
Brush evoked pain 26 97.80 Very High Very High Very High
IPN 2 93.08 High High
Spinal cord 30 89.28 High High
Stimulus evoked pain 4 88.00 High High
Acute pain 4 78.76 Quite High
antagonist 4 68.56 Quite High
Pain 42 66.32 Quite High
allodynia 12 66.32 Quite High
Neuropathic pain 54 64.12 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 40 99.68 Very High Very High Very High
Neuropathic Pain 94 97.80 Very High Very High Very High
Inflammatory Pain 2 93.08 High High
Hypertrophy 2 90.92 High High
Pain 50 88.00 High High
Hypersensitivity 8 87.60 High High
Injury 12 72.48 Quite High
Infection 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynamic regulation of the P2X4 receptor in alveolar macrophages by phagocytosis and classical activation.
Regulation (regulation) of P2X4 receptor in alveolar macrophages
1) Confidence 0.48 Published 2009 Journal Eur. J. Immunol. Section Title Doc Link 19283779 Disease Relevance 0.19 Pain Relevance 0.09
This is the first study of the regulation of P2X(4)R in macrophages by physiological stimuli and presents a picture whereby P2X(4)R become functional in response to initial phagocytic stimuli but return to a non-functional state during sustained activation by classical macrophage activation.
Regulation (regulation) of P2X in macrophages
2) Confidence 0.48 Published 2009 Journal Eur. J. Immunol. Section Abstract Doc Link 19283779 Disease Relevance 0.11 Pain Relevance 0.05
Immunohistochemical analysis demonstrated that many small cells in the dorsal horn on the side of the nerve injury were intensely positive for P2X4R protein.
Regulation (positive) of P2X4R in dorsal horn associated with nervous system injury and dorsal horn
3) Confidence 0.26 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.14 Pain Relevance 0.87
Moreover, it was found that reducing the upregulation of P2X4R protein in spinal microglia by means of intrathecally administered antisense oligodeoxynucleotide targeting P2X4R prevented the development of the nerve injury-induced tactile allodynia.
Regulation (targeting) of P2X4R in nerve associated with brush evoked pain and nervous system injury
4) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.03 Pain Relevance 0.68

General Comments

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