INT158603

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 5.85
Pain Relevance 4.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX4) transport (P2RX4) plasma membrane (P2RX4)
response to stress (P2RX4)
Anatomy Link Frequency
microglial cells 10
nerve 4
mast cell 2
P2RX4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 45 100.00 Very High Very High Very High
Neuropathic pain 81 99.04 Very High Very High Very High
Brush evoked pain 39 98.20 Very High Very High Very High
adenocard 5 97.04 Very High Very High Very High
Stimulus evoked pain 21 96.24 Very High Very High Very High
Dorsal horn 36 93.00 High High
Acute pain 6 92.12 High High
Pain 63 91.32 High High
nMDA receptor 15 83.72 Quite High
antagonist 6 81.92 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 60 99.08 Very High Very High Very High
Neuropathic Pain 139 99.04 Very High Very High Very High
Hypersensitivity 27 96.24 Very High Very High Very High
Pain 90 95.56 Very High Very High Very High
Injury 18 94.64 High High
Inflammatory Pain 1 72.76 Quite High
Intractable Pain 3 60.48 Quite High
Infection 9 58.20 Quite High
Diabetes Mellitus 6 57.68 Quite High
Hypertrophy 3 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phagocytosis rapidly (within 4 h) increased functional P2X(4)R expression by 2- to 7-fold as did chloroquine, an agent known to induce lysosomal secretion.
Positive_regulation (increased) of Gene_expression (expression) of P2X
1) Confidence 0.55 Published 2009 Journal Eur. J. Immunol. Section Abstract Doc Link 19283779 Disease Relevance 0.14 Pain Relevance 0.07
We conclude that mast cell activation has the capacity to promote the expression of P2X4R and BDNF in microglial cells.
Positive_regulation (promote) of Gene_expression (expression) of P2X4R in microglial cells
2) Confidence 0.44 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.35 Pain Relevance 0.22
The results of present study showed that mast cell activation markedly promoted the expression of P2X4R and BDNF in microglial cells, which significantly enhanced the release of BDNF from microglial cells upon exposure to adenosine triphosphate.
Positive_regulation (promoted) of Gene_expression (expression) of P2X4R in microglial cells associated with adenocard
3) Confidence 0.44 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.51 Pain Relevance 0.31
Pretreatment with antibodies against tryptase or PAR2, or using tryptase-deficient HMC-1 cells or PAR2-deficient microglial cells abolished the increase in P2X4R expression and BDNF release.
Positive_regulation (increase) of Gene_expression (expression) of P2X4R in microglial cells
4) Confidence 0.44 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.41 Pain Relevance 0.25
Mast cell-derived tryptase activated PAR2 that resulted in promoting the expression of P2X4R in microglial cells.
Positive_regulation (promoting) of Gene_expression (expression) of P2X4R in microglial cells
5) Confidence 0.32 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.46 Pain Relevance 0.28
The present study aimed to elucidate the mechanism by which mast cell activation promoted the expression of P2X4R in the microglia.
Positive_regulation (promoted) of Gene_expression (expression) of P2X4R in mast cell
6) Confidence 0.30 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.54 Pain Relevance 0.31
These activated microglia express P2X4R; endogenous ATP can then activate these receptors and lead to neuropathic pain.
Positive_regulation (activate) of Gene_expression (express) of P2X4R in microglia associated with neuropathic pain
7) Confidence 0.29 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 0.72 Pain Relevance 0.88
Importantly, the expression of P2X4R in the spinal cord is enhanced, and this is highly restricted to microglia that are activated after nerve injury.
Positive_regulation (enhanced) of Gene_expression (expression) of P2X4R in nerve associated with nervous system injury and spinal cord
8) Confidence 0.27 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.33 Pain Relevance 1.08
The expression of P2X4R protein, normally low in the naïve spinal cord, progressively increased in the days following nerve injury with a time-course parallel to that of the development of tactile allodynia.
Positive_regulation (increased) of Gene_expression (expression) of P2X4R in nerve associated with brush evoked pain, nervous system injury and spinal cord
9) Confidence 0.27 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.38 Pain Relevance 1.16

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