INT158630

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 14.75
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
joint 2
liver 2
Th17 T-cell 2
dendritic cell 2
lung 2
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 36 99.86 Very High Very High Very High
cytokine 280 99.56 Very High Very High Very High
Inflammation 446 99.36 Very High Very High Very High
qutenza 7 99.36 Very High Very High Very High
fibrosis 209 97.74 Very High Very High Very High
Arthritis 79 97.06 Very High Very High Very High
Inflammatory mediators 15 95.20 Very High Very High Very High
dexamethasone 7 85.88 High High
cINOD 19 82.36 Quite High
Inflammatory response 63 77.36 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 87 99.68 Very High Very High Very High
Hepatocellular Cancer 91 99.40 Very High Very High Very High
INFLAMMATION 480 99.36 Very High Very High Very High
Apoptosis 217 99.28 Very High Very High Very High
Arthritis 78 99.08 Very High Very High Very High
Cancer 1404 98.92 Very High Very High Very High
Arthropathy 2 98.68 Very High Very High Very High
Colorectal Cancer 17 98.24 Very High Very High Very High
Inflammatory Bowel Disease 49 97.96 Very High Very High Very High
Pulmonary Fibrosis 137 97.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the two pathways share transcriptional responsiveness of proliferative target genes, such as c-myc and cyclinD1, IL11 administration and excessive Stat3 activation also facilitates survival of epithelial cells with the capacity to repopulate the intestine after radiation damage [92] (Phesse T, Buchert M, Ernst M: Epistatic interaction between aberrant Wnt and Stat3 signaling during intestinal tumorigenesis, submitted).
Positive_regulation (excessive) of Positive_regulation (activation) of Stat3 in intestine
1) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.45 Pain Relevance 0
Meanwhile, IL10-mediated sustained Stat3 activation in TAMs represses IL12 expression and promotes production of IL23 (comprising IL23a/IL12b heterodimers), which helps to propagate the Th17 T-cell subset [129].
Positive_regulation (promotes) of Positive_regulation (activation) of Stat3 in Th17 T-cell
2) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.01 Pain Relevance 0.20
B and Stat3-mediated signaling converge on the EMT process where IL6-mediated Stat3 activation promotes EMT through transcriptional induction of the E-cadherin repressor snail [146], while activation of NF-?
Positive_regulation (mediated) of Positive_regulation (activation) of Stat3
3) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.33 Pain Relevance 0.15
Accordingly, tissue-specific Socs3 ablation in mice amplifies ligand-dependent gp130 signalling, while the Y757F tyrosine-to-phenylalanine substitution in the corresponding gp130Y757F knock-in mutant mice results in excessive activation of Stat3 and Stat1 [30,31].
Positive_regulation (results) of Positive_regulation (activation) of Stat3 associated with targeted disruption
4) Confidence 0.46 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.23 Pain Relevance 0.11
Owing to their capacity to inactivate upstream tyrosine kinases or to sequester phosphorylated Stat3 from de novo Stat-dimers, mutagenic alterations in the cytosolic tyrosine phosphatases CD45 [50,51], SHP1 and SHP2 [50,51], or the SUMO E3 ligase Pias3 [52] and Grim19 [53] are also expected to result in excessive activation of Stat3-dependent target genes.


Positive_regulation (result) of Positive_regulation (activation) of Stat3
5) Confidence 0.46 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.79 Pain Relevance 0.03
Consistent with this finding, we also observed that enforced, ligand-independent activation of endogenous Stat3 in the epithelium of the small and large intestine failed to confer tumour development in transgenic mice [96].
Positive_regulation (enforced) of Neg (independent) Positive_regulation (activation) of Stat3 in large intestine associated with targeted disruption and cancer
6) Confidence 0.46 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.59 Pain Relevance 0.11
However, a variety of cancers harbour activating point mutations in Jak2 [44] and gp130 in-frame deletion mutations, which mediate ligand-independent activation of Stat3, are found in hepatocellular carcinomas [45].
Positive_regulation (mediate) of Neg (independent) Positive_regulation (activation) of Stat3 associated with cancer and hepatocellular cancer
7) Confidence 0.46 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.83 Pain Relevance 0.17
Stat3 activity in tumor cells inhibits the production of pro-inflammatory cytokines and chemokines while inducing the release of factors that inhibit dendritic cell (DC) maturation through activation of Stat3 in DCs.
Positive_regulation (inducing) of Positive_regulation (activation) of Stat3 in dendritic cell associated with chemokine, inflammation, cancer and cytokine
8) Confidence 0.42 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.64 Pain Relevance 0.20
Fourthly, the TLR2 activation of Stat3 is partially dependent of IL-6 and IL-10.
Spec (partially) Positive_regulation (dependent) of Positive_regulation (activation) of Stat3
9) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.66 Pain Relevance 0.03
However, one of the first indications that IL-7 was likely to play a critical role in experimental inflammatory arthritis also stemmed from the earlier studies by Sawa et al. [56] who showed that mice homozygous for the F759 mutation in the gp130/IL-6R subunit showed elevated Stat3 activation and a rheumatoid-like arthritic joint disease.
Positive_regulation (elevated) of Positive_regulation (activation) of Stat3 in joint associated with inflammation, arthropathy and arthritis
10) Confidence 0.36 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.94 Pain Relevance 0.43
Interestingly, conditional STAT3 deletion in neutrophils also exhibited hyper-responses to G-CSF [48], suggesting that a major role of STAT3 in neutrophils is the induction of SOCS3.
Positive_regulation (induction) of Positive_regulation (role) of STAT3 in neutrophils
11) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.59 Pain Relevance 0.08
were correlated with increased ROS accumulation, which led to JNK and STAT3 activation.
Positive_regulation (led) of Positive_regulation (activation) of STAT3
12) Confidence 0.33 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.22 Pain Relevance 0.07
Furthermore, recent studies show that STAT3 activation is increased, and SOCS3 is silenced in tumors of patients with ulcerative colitis-associated and sporadic CRC [2,17].
Positive_regulation (increased) of Positive_regulation (activation) of STAT3 associated with colorectal cancer, inflammatory bowel disease and cancer
13) Confidence 0.27 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.86 Pain Relevance 0.25
in inflammation upregulate the IL-6 expression (20), and IL-6 stimulation in the liver induces the translocation of activated STAT3 molecules to nuclei (21,22).
Positive_regulation (induces) of Positive_regulation (activated) of STAT3 in liver associated with inflammation
14) Confidence 0.22 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.80 Pain Relevance 0.53
It was recently reported that capsaicin inhibited interleukin-6 (IL-6)-induced activation of signal transducer and activator of transcription 3 (STAT3), an anti-apoptotic transcription factor.
Positive_regulation (induced) of Positive_regulation (activation) of signal transducer and activator of transcription 3 associated with qutenza and apoptosis
15) Confidence 0.21 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19285962 Disease Relevance 0.49 Pain Relevance 0.42
signaling pathway, and (3) increased activation of STAT-3.
Positive_regulation (increased) of Positive_regulation (activation) of STAT-3
16) Confidence 0.20 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.79 Pain Relevance 0.12
These findings indicate that STAT-1-/- mice are more susceptible to bleomycin-induced lung fibrosis than STAT-1+/+ mice owing to enhanced fibroblast proliferation in response to growth factors (PDGF and EGF) and increased activation of STAT-3.
Positive_regulation (increased) of Positive_regulation (activation) of STAT-3 in lung associated with fibrosis and pulmonary fibrosis
17) Confidence 0.14 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.52 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox