INT158641

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.15
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CHEK2) nucleus (CHEK2) cell cycle (CHEK2)
cell division (CHEK2)
Anatomy Link Frequency
neuronal 1
astrocyte 1
CHEK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 16 83.08 Quite High
Arthritis 1 73.96 Quite High
Rheumatism 1 73.52 Quite High
Neuritis 1 73.04 Quite High
Inflammation 2 71.92 Quite High
Taxol 1 67.76 Quite High
Inflammatory response 1 60.40 Quite High
Central nervous system 2 52.60 Quite High
tolerance 12 37.84 Quite Low
cytokine 1 9.20 Low Low
Disease Link Frequency Relevance Heat
Cancer 138 99.64 Very High Very High Very High
Neuroblastoma 3 99.50 Very High Very High Very High
Disease 231 95.88 Very High Very High Very High
Reprotox - General 1 60 93.68 High High
Breast Cancer 22 92.68 High High
Gliosis 4 91.56 High High
Death 20 87.76 High High
Skin Cancer 18 85.84 High High
Dementia 8 84.32 Quite High
Congenital Anomalies 7 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, activated P-Chk2 was observed in mostly small, non-neuronal cells.
Positive_regulation (activated) of P-Chk2 in neuronal
1) Confidence 0.35 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.82 Pain Relevance 0
This discordance will be pursued in a future study, especially as we have shown that the Chk2 checkpoint kinase protein, a downstream substrate of ATM, is activated in the astrocyte population of the cerebellar dentate nuclei (in keeping with the findings of Myung et al. [42]).
Positive_regulation (activated) of Chk2 in astrocyte
2) Confidence 0.29 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.68 Pain Relevance 0.12
In ovarian and neuroblastoma cancer cells, genistein activates Chk1 and Chk2, which in turn activate, or dephosphorylate, Cdc25C and Cdc25A [56, 58].
Positive_regulation (activates) of Chk2 associated with neuroblastoma and cancer
3) Confidence 0.26 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.76 Pain Relevance 0
The nuclei were diffusely positive for Chk2 and p27, which is considered to be the normal staining pattern for these markers.
Positive_regulation (positive) of Chk2
4) Confidence 0.26 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 0.62 Pain Relevance 0
ATM is predominantly required for Chk2 activation whereas ATR is predominantly required for Chk1 activation, although there is some cross talk between the pathways (reviewed in [54]–[56]).
Positive_regulation (activation) of Chk2
5) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0 Pain Relevance 0
While extracts of P. decumanum showed only moderate anti-cancer activity and were therefore not further analysed, particularly the dichloromethane extract of P. odorata inhibited the cell cycle in G2-M which correlated with the activation of checkpoint kinase 2, and down-regulation of Cdc25A and cyclin D1 as well as inactivation of Erk1/2.
Positive_regulation (activation) of checkpoint kinase 2 associated with cancer
6) Confidence 0.11 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19287970 Disease Relevance 1.27 Pain Relevance 0.25

General Comments

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