INT158644

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.63
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CDC25A) cytosol (CDC25A) nucleoplasm (CDC25A)
mitosis (CDC25A) nucleus (CDC25A) intracellular (CDC25A)
Anatomy Link Frequency
H69 1
CDC25A (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 260 99.76 Very High Very High Very High
Arthritis 1 72.20 Quite High
Rheumatism 1 71.76 Quite High
Neuritis 1 71.28 Quite High
Taxol 1 70.24 Quite High
Inflammation 3 70.16 Quite High
Inflammatory response 1 62.88 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 126 99.34 Very High Very High Very High
Cancer 89 95.82 Very High Very High Very High
Death 3 90.24 High High
Contusions 1 72.88 Quite High
Cough 1 72.52 Quite High
Arthritis 1 72.20 Quite High
Rheumatic Diseases 1 71.76 Quite High
Neuritis 1 71.28 Quite High
INFLAMMATION 4 70.16 Quite High
Disease 8 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment of H69 human SCLC cells with capsaicin leads to a switch in E2F subtypes on cyclin E, TS, cdc25A and cdc6 promoters; E2F1–3 are dissociated from the promoter, and E2F4 and p130 are recruited.
Negative_regulation (switch) of cdc25A in H69 associated with qutenza and small cell lung cancer
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.71 Pain Relevance 0.39
While extracts of P. decumanum showed only moderate anti-cancer activity and were therefore not further analysed, particularly the dichloromethane extract of P. odorata inhibited the cell cycle in G2-M which correlated with the activation of checkpoint kinase 2, and down-regulation of Cdc25A and cyclin D1 as well as inactivation of Erk1/2.
Negative_regulation (regulation) of Cdc25A associated with cancer
2) Confidence 0.16 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19287970 Disease Relevance 1.26 Pain Relevance 0.24
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Negative_regulation (decrease) of cdc25A associated with qutenza
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.67 Pain Relevance 0.91

General Comments

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