INT158666

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.41
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
cortex 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 78 99.38 Very High Very High Very High
Morphine 21 98.06 Very High Very High Very High
withdrawal 7 97.72 Very High Very High Very High
addiction 44 96.04 Very High Very High Very High
narcan 3 95.08 Very High Very High Very High
antidepressant 96 94.20 High High
Pyramidal cell 2 83.16 Quite High
Locus ceruleus 9 77.24 Quite High
Raphe 3 75.88 Quite High
opiate 1 39.56 Quite Low
Disease Link Frequency Relevance Heat
Stress 207 100.00 Very High Very High Very High
Weight Loss 1 98.56 Very High Very High Very High
Morphine Dependence 3 96.40 Very High Very High Very High
Targeted Disruption 90 75.52 Quite High
Drug Dependence 9 66.96 Quite High
Body Weight 16 57.48 Quite High
Opiate Addiction 1 39.96 Quite Low
Recurrence 4 39.60 Quite Low
Depression 43 34.24 Quite Low
Depressive Disorder 3 33.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence.
Regulation (regulated) of Transcription (transcription) of CREB associated with addiction and morphine
1) Confidence 0.45 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.27 Pain Relevance 1.10
The effects of signalling pathways involving adenylate cyclase and cAMP, Ca2+ and different kinases on CREB/CREB-regulated gene transcription are well established[30].
Regulation (regulated) of Transcription (transcription) of CREB
2) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.19
The effects of signalling pathways involving adenylate cyclase and cAMP, Ca2+ and different kinases on CREB/CREB-regulated gene transcription are well established[30].
Regulation (regulated) of Transcription (transcription) of CREB
3) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.19
A good reason for differential CREB or pCREB expression is that different central nuclei and cell populations offer various gene targets for these transcription factors, each likely exhibiting their own sensitivites to changes in the CREB transcription factor to induce gene transcription.
Regulation (changes) of Transcription (transcription) of CREB
4) Confidence 0.44 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0 Pain Relevance 0.03
These findings suggest that morphine reward can influence the expression of RACK1 in mouse hippocampus and prefrontal cortex through regulating CREB transcription.
Regulation (regulating) of Transcription (transcription) of CREB in cortex associated with hippocampus and morphine
5) Confidence 0.42 Published 2009 Journal Neuroscience Section Abstract Doc Link 19341783 Disease Relevance 0.12 Pain Relevance 0.81
Thus, the chronic treatment with imipramine completely abolished the stimulating effect of chronic social stress on CRE/CREB-directed transcription and resulted in levels similar to control.


Regulation (effect) of Transcription (transcription) of CREB associated with stress
6) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.58 Pain Relevance 0.11

General Comments

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