INT158669

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 43
Total Number 46
Disease Relevance 26.82
Pain Relevance 5.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4)
kinase activity (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
nucleus accumbens 2
P19 1
neurons 1
brains 1
LS1 1
Camk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatosensory cortex 9 99.90 Very High Very High Very High
Nucleus accumbens 335 99.80 Very High Very High Very High
antagonist 11 99.50 Very High Very High Very High
dopamine receptor 1 99.28 Very High Very High Very High
amygdala 46 99.08 Very High Very High Very High
Anterior cingulate cortex 170 98.88 Very High Very High Very High
Eae 230 98.76 Very High Very High Very High
long-term potentiation 90 98.66 Very High Very High Very High
analgesia 90 98.16 Very High Very High Very High
gABA 7 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 1502 100.00 Very High Very High Very High
Repression 1074 100.00 Very High Very High Very High
Targeted Disruption 753 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 96 99.66 Very High Very High Very High
Shock 158 98.66 Very High Very High Very High
Stress 227 97.44 Very High Very High Very High
Cognitive Disorder 28 97.44 Very High Very High Very High
Sprains And Strains 63 96.64 Very High Very High Very High
Death 83 95.64 Very High Very High Very High
Congenital Anomalies 21 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of CaMKIV activity did not affect basal locomotor activity.
Negative_regulation (Suppression) of CaMKIV associated with eae
1) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.18 Pain Relevance 0.43
In situ hybridization analysis with a radioactive oligonucleotide probe revealed that CaMKIV mRNA was completely attenuated in brains of CaMKIV null mice and the expression level was decreased by about 50% in brains of heterozygous mice (Fig. 1C).
Negative_regulation (attenuated) of CaMKIV in brains
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.53 Pain Relevance 0.03
Despite some minor differences, our observation is consistent with the results reported by Wei et al that CaMKIV deficiency causes a performance deficit in the contextual and cued fear conditioning test [33].
Negative_regulation (deficiency) of CaMKIV associated with anxiety disorder
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.16 Pain Relevance 0
To evaluate the behavioral effects of CaMKIV deficiency, we subjected CaMKIV KO mice and their wild-type littermates to a comprehensive battery of behavioral tests (Table 1) [13].
Negative_regulation (deficiency) of CaMKIV associated with targeted disruption
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.75 Pain Relevance 0.06
Those results suggest that CaMKIV deficiency causes a mild decrease in anxiety-like behavior.
Negative_regulation (deficiency) of CaMKIV associated with anxiety disorder
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.66 Pain Relevance 0
CaMKIV deficiency resulted in mildly decreased anxiety-like behavior in the light/dark transition test and the elevated plus maze test.
Negative_regulation (deficiency) of CaMKIV associated with anxiety disorder
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.79 Pain Relevance 0
Here, we used two different fear-based memory paradigms to more carefully dissect the effects of CaMKIV deficiency.
Negative_regulation (deficiency) of CaMKIV associated with anxiety disorder
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 1.13 Pain Relevance 0
Means and coworkers demonstrated that the targeted disruption of the CaMKIV gene results in impaired cerebellar LTD and motor control [12] while the other knockout strain [13] had mild cerebellar abnormalities and deficits in long-term potentiation (LTP).
Negative_regulation (disruption) of CaMKIV gene associated with targeted disruption, congenital anomalies, long-term potentiation and sprains and strains
8) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.84 Pain Relevance 0.13
We have shown that inhibition of endogenous CaMKIV activity attenuated Ca2+-induced expression of c-fos (Fig. 1B) and increases anxiety-like behaviour after viral transfer to the NAc.
Spec (like) Negative_regulation (inhibition) of CaMKIV associated with nucleus accumbens and anxiety disorder
9) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.40 Pain Relevance 0.19
Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice

Background

Negative_regulation (suppression) of Ca2+/calmodulin kinase IV in nucleus accumbens associated with nucleus accumbens
10) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Title Doc Link PMC2219998 Disease Relevance 0.13 Pain Relevance 0.18
In the present study we detected an anxiogenic phenotype after NAc-specific suppression of CaMKIV function.
Negative_regulation (suppression) of CaMKIV associated with nucleus accumbens
11) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.72 Pain Relevance 0.38
We addressed the consequences of suppression of CaMKIV function exclusively in the NAc of adult mice.
Negative_regulation (suppression) of CaMKIV associated with nucleus accumbens
12) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.26 Pain Relevance 0.38
We examined the acoustic startle response and PPI in mice lacking CaMKIV.
Spec (examined) Negative_regulation (lacking) of CaMKIV associated with post-traumatic stress disorder
13) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.78 Pain Relevance 0.06
In the present study, we show that the genetic disruption of CaMKIV in mice results in a decrease in anxiety-like behavior and the abolishment of stress-induced analgesia.
Negative_regulation (disruption) of CaMKIV associated with stress, anxiety disorder and analgesia
14) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.94 Pain Relevance 0.45
However, mice lacking CaMKIV did not show hyperlocomotor activities in the open field [15].
Negative_regulation (lacking) of CaMKIV
15) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.66 Pain Relevance 0.07
The results of the RT-PCR were consistent with those from GeneChip analysis, showing a decrease in oxytocin mRNA in CaMKIV-/-.
Negative_regulation (decrease) of CaMKIV
16) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.78 Pain Relevance 0.33
CaMKIV-/-exhibited a decrease in anxiety-like behavior in both the elevated plus maze and dark-light emergence tests when compared to wild-type mice.
Negative_regulation (decrease) of CaMKIV associated with anxiety disorder
17) Confidence 0.38 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1208947 Disease Relevance 0.78 Pain Relevance 0.08
The increased activity in the center of the open field implied a decrease in anxiety of CaMKIV-/- over wild-type mice [37].


Negative_regulation (decrease) of CaMKIV associated with anxiety disorder
18) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079936 Disease Relevance 0.30 Pain Relevance 0.24
Our previous work demonstrated that mice lacking CaMKIV had a defect in fear memory while behavioral responses to noxious stimuli were unchanged.
Negative_regulation (lacking) of CaMKIV associated with anxiety disorder
19) Confidence 0.38 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1079936 Disease Relevance 0.52 Pain Relevance 0.21
To disrupt CaMKIV, the exon containing an initiation codon for CaMKIV?
Negative_regulation (disrupt) of CaMKIV
20) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.92 Pain Relevance 0

General Comments

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