INT158672

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 4.79
Pain Relevance 5.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calm1) nucleoplasm (Calm1) cytoskeleton (Calm1)
cell cycle (Calm1) cellular_component (Calm1) biological_process (Calm1)
Anatomy Link Frequency
striatum 1
Calm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
complementary and alternative medicine 1242 100.00 Very High Very High Very High
Arthritis 152 100.00 Very High Very High Very High
rheumatoid arthritis 58 99.36 Very High Very High Very High
Spinal cord 6 98.08 Very High Very High Very High
Acupuncture 64 96.20 Very High Very High Very High
Inflammation 44 92.80 High High
Multiple sclerosis 746 87.20 High High
Pain 20 86.00 High High
dopamine receptor 1 58.56 Quite High
antagonist 3 57.12 Quite High
Disease Link Frequency Relevance Heat
Arthritis 104 100.00 Very High Very High Very High
Immune System Diseases 8 99.90 Very High Very High Very High
Chronic Disease 94 99.70 Very High Very High Very High
Rheumatoid Arthritis 60 99.36 Very High Very High Very High
Frailty 6 98.36 Very High Very High Very High
Cv Unclassified Under Development 6 97.44 Very High Very High Very High
Pneumothorax 6 96.68 Very High Very High Very High
Adverse Drug Reaction 8 95.40 Very High Very High Very High
Injury 12 94.84 High High
INFLAMMATION 52 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of patients used CAM for a specific medical reason.
Positive_regulation (used) of CAM associated with complementary and alternative medicine
1) Confidence 0.44 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0 Pain Relevance 0.43
Other studies have also shown that patients suffering from chronic diseases have a higher usage of CAM than those who don't [4,29-34].
Positive_regulation (usage) of CAM associated with complementary and alternative medicine and chronic disease
2) Confidence 0.44 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0.19 Pain Relevance 0.48
Unlike previously reported [25], we have not found higher education level to be associated with a higher usage of CAM (p = 0.30).
Positive_regulation (usage) of CAM associated with complementary and alternative medicine
3) Confidence 0.44 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0 Pain Relevance 0.31
The choice of CAM has been analysed both as a positive choice towards CAM and a negative choice towards the established health care system (Astin, 1998; Siapush, 1998).
Spec (analysed) Positive_regulation (choice) of CAM associated with complementary and alternative medicine
4) Confidence 0.43 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.41 Pain Relevance 0.54
In the Norwegian context, a recent study among the general population shows that, “over the previous 12 months”, 48.7% of the respondents had received CAM by CAM practitioners outside of or by health care personnel inside the health care system.
Positive_regulation (received) of CAM associated with complementary and alternative medicine
5) Confidence 0.43 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.25 Pain Relevance 0.63
The patients redefine the concept of treatment and define what they find useful in CAM
Positive_regulation (useful) of CAM associated with complementary and alternative medicine
6) Confidence 0.43 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.51 Pain Relevance 0.35
The explorers’ choice and use of CAM can be analysed both as a positive choice towards CAM (Foote-Ardah, 2003; Goldstein, 2003; Thorne et al., 2002) and as a negative choice towards the established health care system (Astin, 1998; Siapush, 1998).
Spec (analysed) Positive_regulation (choice) of CAM associated with complementary and alternative medicine
7) Confidence 0.43 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.06 Pain Relevance 0.25
With increasing use of CAM worldwide, orthodox medical practitioners need to be aware of the potential use of CAM by patients.
Positive_regulation (increasing) of CAM associated with complementary and alternative medicine
8) Confidence 0.41 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0.08 Pain Relevance 0.61
Patients suffering from 3 or more medical conditions were more likely to use a higher number of CAM than those suffering from less than 3 medical conditions – see figure 2 (p = < 0.0001).
Positive_regulation (number) of CAM associated with complementary and alternative medicine
9) Confidence 0.41 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0 Pain Relevance 0.37
With increasing CAM popularity, it is important that orthodox medical practitioners are aware of these potential side effects posed by the usage of CAM and should routinely enquire patients regarding CAM use.


Positive_regulation (increasing) of CAM associated with complementary and alternative medicine
10) Confidence 0.41 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0.65 Pain Relevance 0.53
Over the years, increasing proportion of patients with RA and other immune disorders are resorting to complementary and alternative medicine (CAM) for their health needs.
Positive_regulation (resorting) of CAM associated with complementary and alternative medicine, rheumatoid arthritis and immune system diseases
11) Confidence 0.10 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC3014691 Disease Relevance 1.26 Pain Relevance 0.62
In this paper, we have outlined the major immunological pathways involved in the induction and regulation of autoimmune arthritis and described various herbal CAM that can effectively modulate these immune pathways.
Positive_regulation (induction) of CAM associated with complementary and alternative medicine and arthritis
12) Confidence 0.09 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC3014691 Disease Relevance 1.21 Pain Relevance 0.67
Results indicated that repeated treatment with haloperidol, clozapine or risperidone increased CaM protein and CaMII mRNA levels but decreased calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) IV (CaMKIV), kinase alpha (CaMKKalpha), kinase beta (CaMKKbeta) and calcineurin protein levels in the striatum of Sprague-Dawley rats (Rattus Norvegicus).
Positive_regulation (increased) of CaMII mRNA in striatum
13) Confidence 0.07 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.16 Pain Relevance 0.06

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