INT158675

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.13
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Camkk1) cytoplasm (Camkk1)
Camkk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 1 99.84 Very High Very High Very High
antidepressant 1 99.62 Very High Very High Very High
Arthritis 22 94.70 High High
agonist 132 93.24 High High
antagonist 1 86.60 High High
dopamine receptor 1 86.16 High High
rheumatoid arthritis 36 83.44 Quite High
Inflammation 26 82.56 Quite High
Potency 12 73.60 Quite High
cytokine 22 72.80 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 3 96.28 Very High Very High Very High
Arthritis 16 94.70 High High
Experimental Arthritis 12 92.58 High High
Rheumatoid Arthritis 38 83.44 Quite High
INFLAMMATION 32 82.56 Quite High
Osteoporosis 2 71.04 Quite High
Stress 4 69.20 Quite High
Cancer 6 63.60 Quite High
Necrosis 4 63.12 Quite High
Kaposis Sarcoma 2 13.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mood stabilizers such as lithium and valproic acid or the antidepressant fluoxetine had no effect on CaMKIV, CaMKKalpha, CaMKKbeta and calcineurin with the exception of an increase in CaMKKbeta following lithium treatment.
Neg (no) Regulation (effect) of CaMKKalpha associated with antidepressant and fluoxetine
1) Confidence 0.03 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.10 Pain Relevance 0.24
The suppressive effect of ATRA on the activation of activator protein-1 (AP-1) and nuclear factor-IL-6 (NF-IL-6) was reproduced by the MEK1 (mitogen-activated protein extracellularly regulated kinase kinase 1) inhibitor PD-98059, whereas ATRA and PD-98059 had no effect on NF-?
Regulation (regulated) of kinase kinase 1
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656246 Disease Relevance 0.08 Pain Relevance 0.22
AA: adjuvant arthritis; AP-1: activator protein-1; ATRA: all-trans retinoic acid; bp: base pair; CIA: collagen-induced arthritis; Ct: threshold cycle; DMSO: dimethyl sulfoxide; ELISA: enzyme-linked immunosorbent assay; ERK: extracellularly regulated kinase; IL: interleukin; JNK: c-Jun N-terminal kinase; MAPK: mitogen-activated protein kinase; MEK1: mitogen-activated protein extracellularly regulated kinase kinase 1; MMP: matrix metalloprotease; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide; NF-IL-6: nuclear factor of interleukin-6; NF-?
Regulation (regulated) of kinase kinase 1 associated with agonist, experimental arthritis and arthritis
3) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.96 Pain Relevance 0.56

General Comments

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