INT158678

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Lta4h) nucleolus (Lta4h) nucleus (Lta4h)
cytoplasm (Lta4h)
Lta4h (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 6 99.68 Very High Very High Very High
Inflammation 5 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 99.68 Very High Very High Very High
Sickle Cell Anemia 4 98.36 Very High Very High Very High
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low
Nocardia Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, orientation 1 in Figure 7 shows, in the centre of the Ap-B molecule corresponding to the active site (substrate binding site), a negative potential versus a neutral/positive potential for LTA4H.
Positive_regulation (potential) of LTA4H
1) Confidence 0.33 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0
Urinary cysteinyl leukotriene E4 significantly increases during pain in children and adults with sickle cell disease.
Positive_regulation (increases) of leukotriene E4 associated with sickle cell anemia and pain
2) Confidence 0.00 Published 2009 Journal Am. J. Hematol. Section Title Doc Link 19291727 Disease Relevance 0.55 Pain Relevance 0.55

General Comments

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