INT158689

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
SH-SY5Y 2
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 10 97.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 2 99.34 Very High Very High Very High
Apoptosis 4 97.78 Very High Very High Very High
Cancer 1 40.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the present study clearly shows that morphine-induced apoptosis in SH-SY5Y cells involves JNK-dependent activation of the mitochondrial death pathway, and that ROS signaling exerts positive feedback regulation of JNK activity.
Positive_regulation (exerts) of Regulation (regulation) of JNK in SH-SY5Y associated with apoptosis, death and morphine
1) Confidence 0.46 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292871 Disease Relevance 0.41 Pain Relevance 0.60

General Comments

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