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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.09

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cytosol (HMBS) small molecule metabolic process (HMBS) nucleus (HMBS)
cytoplasm (HMBS)
HMBS (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 1 90.32 High High
Disease Link Frequency Relevance Heat
Porphyria 6 100.00 Very High Very High Very High
Hepatic Porphyrias 1 99.72 Very High Very High Very High
Abdominal Pain 1 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute intermittent porphyria is an autosomal dominantly inherited disorder, classified as acute hepatic porphyria, caused by a deficiency of hydroxymethylbilane synthase (EC, EC, also known as porphobilinogen deaminase, uroporphyrinogen I synthase), the third enzyme in heme biosynthesis.
Negative_regulation (deficiency) of Gene_expression (biosynthesis) of hydroxymethylbilane synthase associated with porphyria and hepatic porphyrias
1) Confidence 0.25 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292878 Disease Relevance 0.67 Pain Relevance 0.09

General Comments

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