INT158707

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX4) transport (P2RX4) extracellular region (Bdnf)
cytoplasmic membrane-bounded vesicle (Bdnf) plasma membrane (P2RX4) response to stress (P2RX4)
Anatomy Link Frequency
microglia 2
P2RX4 (Homo sapiens)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Stimulus evoked pain 3 97.88 Very High Very High Very High
Spinal cord 1 94.24 High High
Dorsal horn 1 93.48 High High
Peripheral nerve injury 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 1 98.36 Very High Very High Very High
Pain 3 97.88 Very High Very High Very High
Hypersensitivity 3 97.84 Very High Very High Very High
Nervous System Injury 2 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that P2X4 purinoceptors (P2X4Rs) cause the release of brain-derived neurotrophic factor (BDNF) from microglia, which is necessary for maintaining pain hypersensitivity after nerve injury.
P2X4 Positive_regulation (cause) of Localization (release) of BDNF in microglia associated with nervous system injury, hypersensitivity and stimulus evoked pain
1) Confidence 0.40 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.59 Pain Relevance 0.29

General Comments

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