INT158708

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX4) transport (P2RX4) extracellular region (Bdnf)
cytoplasmic membrane-bounded vesicle (Bdnf) plasma membrane (P2RX4) response to stress (P2RX4)
P2RX4 (Homo sapiens)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Stimulus evoked pain 3 72.32 Quite High
Peripheral nerve injury 1 65.28 Quite High
Spinal cord 1 60.08 Quite High
Dorsal horn 1 59.32 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 73.08 Quite High
Hypersensitivity 3 72.32 Quite High
Pain 3 71.64 Quite High
Injury 1 64.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The late phase of BDNF release and accumulation, but not the early phase of release, are suppressed by inhibiting transcription and translation, indicating that activation of P2X4R causes an initial release of a pre-existing pool of BDNF followed by an increase in de novo synthesis of BDNF.
Positive_regulation (activation) of P2X4R Positive_regulation (causes) of Localization (release) of BDNF
1) Confidence 0.09 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.48 Pain Relevance 0.30

General Comments

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