INT158710

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Cdk5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 22 99.04 Very High Very High Very High
intrathecal 2 92.48 High High
Morphine 9 89.20 High High
Antinociceptive 7 88.84 High High
tolerance 9 88.20 High High
Analgesic 1 73.04 Quite High
Pain management 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies indicated that inhibition of Cdk5 activity or overexpression of a DOR mutant lacking the Cdk5 phosphorylation site displayed relatively low cell surface expression and relatively low abilities to form heterodimers of DOR and MOR; intrathecal delivery of a construct expressing the T161A mutant of DOR attenuated morphine antinociceptive tolerance in rats, suggesting that Thr-161 phosphorylation of DOR contributed to Cdk5-mediated morphine antinociceptive tolerance.
Negative_regulation (inhibition) of Cdk5 Binding (activity) of associated with tolerance, opioid receptor, antinociceptive, morphine and intrathecal
1) Confidence 0.40 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.84

General Comments

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