INT158718

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.32
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Chia) hydrolase activity, acting on glycosyl bonds (Chia) extracellular region (Chia)
carbohydrate metabolic process (Chia) cytoplasm (Chia)
Anatomy Link Frequency
exoskeletons 1
Chia (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 17 98.20 Very High Very High Very High
Inflammatory response 7 97.84 Very High Very High Very High
Inflammation 35 96.00 Very High Very High Very High
cINOD 1 42.48 Quite Low
corticosteroid 1 40.16 Quite Low
antagonist 1 36.16 Quite Low
tolerance 16 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 41 100.00 Very High Very High Very High
INFLAMMATION 40 97.48 Very High Very High Very High
Pneumonia 4 96.40 Very High Very High Very High
Disease 12 84.48 Quite High
Parasitic Infection 1 66.80 Quite High
Hypersensitivity 5 50.16 Quite High
Nicotine Addiction 46 50.00 Quite Low
Salivary Gland Disease 12 28.72 Quite Low
Targeted Disruption 1 25.00 Low Low
Rhinitis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the status of these genes, the same RNA samples that had been subjected to the microarray assay underwent qRT-PCR to determine differential expression of 14 genes previously associated with asthma by other investigators (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Pde4b, Pde4d, Slc7a2, Tgfb1), as well as 7 cytokine genes associated with asthma and/or pulmonary inflammation (Ifn?
Spec (determine) Gene_expression (expression) of Chia associated with asthma, inflammation, pneumonia and cytokine
1) Confidence 0.51 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.38 Pain Relevance 0.14
Chitinases (e.g., chitotriosidase and acidic mammalian chitinase) are enzymes that degrade chitin, the second most abundant biopolymer that can be found in the cell walls of fungi, microfilarial sheaths of helminths, and exoskeletons of insects and crustaceans.
Gene_expression (e.g.) of mammalian chitinase in exoskeletons
2) Confidence 0.34 Published 2009 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 19295241 Disease Relevance 0.94 Pain Relevance 0.16
Changes in the expression levels of the acidic mammalian chitinase precursor and in one of the 14 salivary ?
Gene_expression (expression) of mammalian chitinase precursor
3) Confidence 0.07 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC3018447 Disease Relevance 0 Pain Relevance 0
Additionally, we demonstrated that mouse SFWS 2-DE profile changes in response to introducing quebracho tannins into diet, namely by increasing the expression of one salivary amylase isoform and decreasing the expression of the acidic mammalian chitinase precursor.
Gene_expression (expression) of mammalian chitinase precursor
4) Confidence 0.07 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3018447 Disease Relevance 0 Pain Relevance 0

General Comments

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