INT15872

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2011
Negated 5
Speculated 1
Reported most in Body
Documents 74
Total Number 77
Disease Relevance 45.35
Pain Relevance 6.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
blood 2
leg 2
liver 1
cerebrospinal fluid 1
puncture 1
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 109 100.00 Very High Very High Very High
cINOD 22 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Angina 27 99.40 Very High Very High Very High
Inflammation 79 98.84 Very High Very High Very High
alcohol 14 98.44 Very High Very High Very High
Pain score 4 98.34 Very High Very High Very High
cytokine 55 97.44 Very High Very High Very High
transdermal 10 96.10 Very High Very High Very High
ischemia 8 93.24 High High
Disease Link Frequency Relevance Heat
Hypoxia 894 100.00 Very High Very High Very High
INFLAMMATION 83 100.00 Very High Very High Very High
Renal Failure 71 100.00 Very High Very High Very High
Thrombosis 12 100.00 Very High Very High Very High
Convulsion 7 100.00 Very High Very High Very High
Renal Disease 131 99.98 Very High Very High Very High
Anaemia 668 99.90 Very High Very High Very High
Erythrocytosis 47 99.90 Very High Very High Very High
Renal Cancer 21 99.90 Very High Very High Very High
Heart Failure 129 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5th patient had a significant rise in Hct when the dosage of rHuEPO was increased to 150 units/kg from the 4th to 7th week.
Positive_regulation (increased) of rHuEPO
1) Confidence 0.70 Published 1991 Journal J. Rheumatol. Section Abstract Doc Link 1941817 Disease Relevance 0.74 Pain Relevance 0.23
After the patient's iron supplementation was increased, his Hb level was normalized back to >13.0 g/dl without increasing the epoetin dose, and the angina symptoms were resolved.
Neg (without) Positive_regulation (increasing) of epoetin associated with angina
2) Confidence 0.67 Published 2005 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 15958826 Disease Relevance 0.74 Pain Relevance 0.19
As part of her medication the required dose of erythropoietin was increased from a mean weekly dose of 8000 units to 14000 units during pregnancy to maintain a hemoglobin level of 10 gm/dl.
Positive_regulation (increased) of erythropoietin
3) Confidence 0.64 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2278151 Disease Relevance 0.21 Pain Relevance 0
As expected, erythropoietin and iron requirements were increased during her pregnancy (erythropoietin from a weekly dose of 6000 to a mean of 14000 units and iron saccharate to 100 mg IV once every week instead of 100 mg/day of oral ferrous fumarate).
Positive_regulation (increased) of erythropoietin
4) Confidence 0.64 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2278151 Disease Relevance 0.51 Pain Relevance 0
This is consistent with our observation, as erythropoietin doses were increased (by more than 70% and 100% in case 1 and 2 respectively) to maintain hemoglobin level comparable to that before pregnancy.
Positive_regulation (increased) of erythropoietin
5) Confidence 0.64 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2278151 Disease Relevance 0.48 Pain Relevance 0.05
These findings are in agreement with the literature showing that Epo and EpoR are upregulated by hypoxia-inducible factors [15-18].
Positive_regulation (upregulated) of Epo associated with hypoxia
6) Confidence 0.64 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.86 Pain Relevance 0.08
Peak leg O2 delivery increased after rhEpo in normoxia only (Fig. 6F).
Positive_regulation (increased) of rhEpo in leg
7) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0.68 Pain Relevance 0
Indeed, we found that blood pressure during normoxic maximal exercise increased after rhEpo.
Positive_regulation (increased) of rhEpo in blood
8) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0.13 Pain Relevance 0
The sensitivity, specificity and the positive and negative predictive values in detecting a follow-up haemoglobin < 11.0 g/dL were calculated by interpreting the decision of the nephrologists to increase the epoetin dose as if it had been a prediction of a follow-up haemoglobin below the target level.
Positive_regulation (increase) of epoetin
9) Confidence 0.52 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1578551 Disease Relevance 0 Pain Relevance 0
This finding, compared with the performance of the nephrologists in the same group (the epoetin dose would have been increased in 4 patients with a follow-up haemoglobin > 12.0 g/dL without adaptation in the dose), offers sufficient guarantees for the application of the selected ANNs in the clinical setting.
Positive_regulation (increased) of epoetin
10) Confidence 0.52 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1578551 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: After an intravenous infusion of epoetin alpha, radiotherapy and steroids, high concentrations of erythropoietin were detectable in the cerebrospinal fluid.
Positive_regulation (concentrations) of erythropoietin in cerebrospinal fluid
11) Confidence 0.50 Published 2007 Journal Clin Oncol (R Coll Radiol) Section Body Doc Link 17305256 Disease Relevance 0 Pain Relevance 0
MATERIALS AND METHODS: Ten paraparetic patients with malignant extradural spinal cord compression who were eligible for radiotherapy, lumbar puncture and intravenous epoetin alpha were enrolled.
Positive_regulation (eligible) of epoetin alpha in puncture
12) Confidence 0.50 Published 2007 Journal Clin Oncol (R Coll Radiol) Section Body Doc Link 17305256 Disease Relevance 0.09 Pain Relevance 0
The objective of these two studies was to compare the safety, tolerability, pharmacokinetics, and pain score at the subcutaneous (sc) injection site of a phosphate-buffered recombinant human erythropoietin (EPREX, epoetin alfa, r-HuEPO) formulated with a new stabilizer (glycine and Polysorbate 80) with the commercially available EPREX formulations, which uses human serum albumin (HSA) as the stabilizer.
Positive_regulation (formulated) of erythropoietin associated with pain score
13) Confidence 0.50 Published 2000 Journal Biopharm Drug Dispos Section Abstract Doc Link 11304719 Disease Relevance 0.10 Pain Relevance 0.10
In addition, preoperative administration of human recombinant erythropoietin was introduced during the last year of the study.
Positive_regulation (introduced) of erythropoietin
14) Confidence 0.50 Published 1999 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 10102398 Disease Relevance 0.18 Pain Relevance 0.07
Glomerulonephritis influenced EPO to a higher dose, but not Hb.
Neg (not) Positive_regulation (influenced) of EPO associated with renal disease
15) Confidence 0.50 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2621153 Disease Relevance 1.04 Pain Relevance 0
The requirement of EPO for each section of mean Hb level is shown in the figure.
Positive_regulation (requirement) of EPO
16) Confidence 0.50 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2621153 Disease Relevance 0.35 Pain Relevance 0
RESULTS: During OL HDF, hemoglobin values significantly increased in patients without addition of recombinant human erythropoietin (rHuEPO): baseline vs. 6 months 11 +/- 1.7 vs. 12 +/- 1.8 g/dl (p < 0.01); baseline vs. 9 months 11 +/- 1.7 vs. 12 +/- 1.6 g/dl (p < 0.05).
Positive_regulation (increased) of rHuEPO
17) Confidence 0.50 Published 2002 Journal Blood Purif. Section Body Doc Link 12169845 Disease Relevance 0 Pain Relevance 0
Nonetheless, accumulating evidence of undesirable effects has led regulatory authorities to mandate increasing restrictions on the use of epoetin beta and other ESAs.
Positive_regulation (increasing) of epoetin beta
18) Confidence 0.50 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.36 Pain Relevance 0.07
EPO-alpha ph is better accepted than s.c.
Positive_regulation (accepted) of EPO-alpha
19) Confidence 0.50 Published 1998 Journal Clin. Nephrol. Section Abstract Doc Link 9491285 Disease Relevance 0.36 Pain Relevance 0.51
Hypoxia induces tissue-specific gene products such as erythropoietin (EPO) and vascular endothelial growth factor (VEGF), which improve the peripheral O2 supply, and glucose transporters and glycolytic enzymes, which adapt cells to reduced O2 availability.
Positive_regulation (induces) of erythropoietin associated with hypoxia
20) Confidence 0.49 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11950137 Disease Relevance 0.22 Pain Relevance 0

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