INT158730

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 1.82
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Plxna3) intracellular (Plxna3)
Anatomy Link Frequency
neuronal 1
autonomic 1
Plxna3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1 90.76 High High
Endogenous opioid 1 86.88 High High
Pain 3 85.60 High High
Opioid 1 75.00 Quite High
cerebral cortex 12 5.00 Very Low Very Low Very Low
carbamazepine 10 5.00 Very Low Very Low Very Low
Somatosensory cortex 6 5.00 Very Low Very Low Very Low
member 8 5 5.00 Very Low Very Low Very Low
antiepileptic Drug 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Menopausal Vasomotor Symptoms 1 99.40 Very High Very High Very High
Stress 35 95.80 Very High Very High Very High
Hypertension 5 91.28 High High
Anxiety Disorder 1 90.24 High High
Sprains And Strains 12 89.28 High High
Pain 3 85.60 High High
Repression 15 82.32 Quite High
Aging 110 80.32 Quite High
Body Weight 34 66.40 Quite High
Acute-phase Reaction 10 61.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The natural selective estrogen receptor modulator DT56a (Femarelle), derived from soybean, has been shown to relieve menopausal vasomotor symptoms with no effect on sex steroid hormone levels or endometrial thickness.The purpose of the present study was to evaluate the neuroendocrine effect of DT56a administration through the evaluation of brain content of allopregnanolone (AP), an endogenous neurosteroid gamma-aminobutyric acid agonist with anxiolytic properties, and through the assessment of beta-endorphin (beta-END), the endogenous opioid implicated in pain mechanism, emotional state, and autonomic control.
Gene_expression (levels) of sex in autonomic associated with pain, anxiety disorder, endogenous opioid, agonist and menopausal vasomotor symptoms
1) Confidence 0.65 Published 2009 Journal Menopause Section Abstract Doc Link 19295450 Disease Relevance 0.28 Pain Relevance 0.29
There was no Lesion × Sex interaction (F 2,36 < 1), nor main effect of Sex (F 1,36 <1).


Neg (no) Gene_expression (interaction) of Sex
2) Confidence 0.18 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC166148 Disease Relevance 0.24 Pain Relevance 0
There was no Lesion × Sex interaction (F 2,36 < 1), nor main effect of Sex (F 1,36 <1).


Gene_expression (effect) of Sex
3) Confidence 0.18 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC166148 Disease Relevance 0.24 Pain Relevance 0
To discover further large-scale patterns of sex-specific life cycle gene expression, the data were analyzed on a per-age group basis assessing the number of instances where the expression difference of a given gene between the sexes was at least 2-fold, with the condition that the data at that individual age group first met the screening criteria of p < 0.05 and great than or equal to 1.5 relative fold-change (Figure 4).
Gene_expression (expression) of sex-specific
4) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.32 Pain Relevance 0
Based upon the known common pathway (Dbp and Tef controlled by the SCN) and life cycle expression data exhibiting correlated and sex-specific patterns, these data suggest a shared regulatory mechanism between the PARzip family members' expression and the sex-specific pattern of SCN neuronal deterioration.
Gene_expression (expression) of sex-specific in neuronal
5) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Furthermore, specific periods of the life cycle were identified that display a higher number of genes with sex-specific expression which included putative toxicological susceptibility related genes (e.g., Cyp2d4, Cyp3a23/3a1, Gstm1, Slc22a8).
Gene_expression (expression) of sex-specific
6) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.17 Pain Relevance 0
Namely, principal component analysis identified and ranked genes which exhibited the greatest sex-specific and sex-conserved differential expression.
Gene_expression (expression) of sex-specific
7) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.17 Pain Relevance 0
From the ages of 21 to 78 weeks, sex-predominant gene expression was higher in males than females.
Gene_expression (expression) of sex-predominant
8) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.41 Pain Relevance 0

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