INT158738

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.49
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleus (Pgr) enzyme binding (Pgr)
DNA binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
lymph nodes 1
brain 1
endometrium 1
Pgr (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 9 99.12 Very High Very High Very High
cytokine 35 69.48 Quite High
agonist 4 58.76 Quite High
withdrawal 4 56.08 Quite High
Inflammation 54 46.32 Quite Low
headache 1 29.12 Quite Low
abdominal pain 1 28.24 Quite Low
carbamazepine 2 5.84 Low Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 66 100.00 Very High Very High Very High
Reprotox - General 1 10 99.12 Very High Very High Very High
Breast Cancer 21 99.06 Very High Very High Very High
Dysmenorrhea 6 98.10 Very High Very High Very High
Carcinoma 9 98.00 Very High Very High Very High
Disease 28 97.20 Very High Very High Very High
Targeted Disruption 57 96.28 Very High Very High Very High
Hypersensitivity 1 95.72 Very High Very High Very High
Apoptosis 40 93.68 High High
Creutzfeldt Jakob Disease 6 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The membranes were washed several times with PBST and then incubated with PR Ab-7/hPRa 7 (Ab7; Neomarkers, Union City, CA, USA) or C-19 (Santa Cruz), ER-?
PR Binding (incubated) of
1) Confidence 0.28 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0 Pain Relevance 0
In rodents, direct treatment of DCs with progesterone has been shown to increase the inhibitory capacity of DCs and these changes are associated with progesterone receptor (PR) regulation.
PR Binding (associated) of
2) Confidence 0.08 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.05 Pain Relevance 0.06
In rodents, direct treatment of DCs with progesterone has been shown to increase the inhibitory capacity of DCs and these changes are associated with progesterone receptor (PR) regulation.
progesterone receptor Binding (associated) of
3) Confidence 0.08 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.05 Pain Relevance 0.06
Nuclear p65 immunoreactivity was positively associated with heavier menses, and decreased PR-B and increased nuclear p65 immunoreactivity in ectopic endometrium were statistically significantly associated with the severity of dysmenorrhea in women with adenomyosis.
PR-B Binding (associated) of in endometrium associated with dismenorea
4) Confidence 0.05 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 19296948 Disease Relevance 0.36 Pain Relevance 0.36
Gossypol is clinically used in China to treat adenomyosis and hysteromyoma because of its ability to inhibit estrogen and progesterone by competitively binding to the estrogen receptor and progesterone receptor [28]. c-Myc is a well-established target of estrogen action and plays a role in controlling cell cycle progression.
progesterone receptor Binding (binding) of associated with dismenorea
5) Confidence 0.05 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.05 Pain Relevance 0.10
In breast cancer, two small retrospective studies has shown an association with elevated clusterin expression and large tumor size, estrogen and progesterone receptor status and with the progression from the primary carcinoma to metastatic carcinoma in lymph nodes in breast cancer [32,33].
progesterone receptor Binding (association) of in lymph nodes associated with cancer, breast cancer and carcinoma
6) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 1.30 Pain Relevance 0.03
Since UPA binds the progesterone receptor with high affinity, it may interfere with the action of progestogen-containing drugs.
progesterone receptor Binding (binds) of
7) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971744 Disease Relevance 0.34 Pain Relevance 0
Using immunoprecipitation and mass spectrometry, we have identified a set of proteins associated with PrPmyc.
PrPmyc Binding (associated) of
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.33 Pain Relevance 0
Based on this mass spectrometric approach, we found a small number of protein candidates equimolarly associated with PrPmyc in native brain homogenates.
PrPmyc Binding (associated) of in brain
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0 Pain Relevance 0

General Comments

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