INT158752

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.60
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
RVM 2
TRPV1 (Homo sapiens)
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 16 100.00 Very High Very High Very High
mu opioid receptor 6 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
narcan 4 98.98 Very High Very High Very High
Pain 4 98.90 Very High Very High Very High
antagonist 2 98.24 Very High Very High Very High
opioid receptor 2 98.00 Very High Very High Very High
agonist 4 97.28 Very High Very High Very High
qutenza 4 96.56 Very High Very High Very High
Glutamate 8 92.12 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 16 100.00 Very High Very High Very High
Pain 4 98.90 Very High Very High Very High
Nociception 4 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because both opioid and vanilloid systems integrate and transduce pain sensation in these pathways, we studied the potential interaction between TRPV1 and mu-opioid receptors in the VL-PAG-rostral ventromedial medulla (RVM) system.
TRPV1 Binding (interaction) of RVM in RVM associated with pain, mu opioid receptor, urological neuroanatomy, opioid and rostral ventromedial medulla
1) Confidence 0.05 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19297510 Disease Relevance 0.76 Pain Relevance 1.51
These effects were all antagonized by the TRPV1 and opioid receptor antagonists 5'-iodo-resiniferatoxin and naloxone, respectively, thus suggesting the existence of a TRPV1-mu-opioid interaction in the VL-PAG-RVM system.
TRPV1 Binding (interaction) of RVM in RVM associated with antagonist, narcan, urological neuroanatomy, opioid receptor, opioid and rostral ventromedial medulla
2) Confidence 0.05 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19297510 Disease Relevance 0.84 Pain Relevance 1.59

General Comments

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