INT158754

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.24
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XPA) nucleus (XPA)
Anatomy Link Frequency
MCF-7 1
stem cell 1
XPA (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 1 95.76 Very High Very High Very High
Hsan 4 80.40 Quite High
imagery 2 52.88 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 164 99.44 Very High Very High Very High
Renal Cancer 6 99.40 Very High Very High Very High
Breast Cancer 242 98.96 Very High Very High Very High
Skin Cancer 65 96.20 Very High Very High Very High
Disease 19 96.20 Very High Very High Very High
Low Back Pain 1 95.76 Very High Very High Very High
Fever 1 94.88 High High
Hematuria 1 93.12 High High
Hyperplasia 4 91.84 High High
Hereditary Sensory And Autonomic Neuropathies 4 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The "poor outcome signature" distinguishing tumors unlikely to respond to PST included DDB2 or XPA, involved in DNA damage repair which makes perfect logical sense.
Gene_expression (included) of XPA associated with cancer
1) Confidence 0.57 Published 2005 Journal J Transl Med Section Body Doc Link PMC1201176 Disease Relevance 0.69 Pain Relevance 0.03
Significant association between PTCH1 and XPA deletion in both groups as well as between their methylation in group-B suggested some functional relationship between hedgehog dependent stem cell renewal pathway and the NER pathway.
Gene_expression (deletion) of XPA in stem cell
2) Confidence 0.42 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.38 Pain Relevance 0
The mRNA expression of PHF2, FANCC, PTCH1 and XPA in normal breast tissue (n = 6), and primary BC (n = 14) and 1 cell line (MCF-7) was analyzed by quantitative real-time (Q-PCR).
Spec (analyzed) Gene_expression (expression) of XPA in MCF-7 associated with breast cancer
3) Confidence 0.38 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.33 Pain Relevance 0
Thus an attempt was made in this study to analyze the alterations (deletion, methylation and expression) of PHF2, FANCC, PTCH1 and XPA in early- and late-onset BC of Indian patients and correlate them with clinico-pathological differences.


Spec (analyze) Gene_expression (expression) of XPA associated with breast cancer
4) Confidence 0.38 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 1.41 Pain Relevance 0.08
Compared to XPA, overall frequencies of alterations in PHF2, FANCC and PTCH1 were higher (Figure 4).
Gene_expression (higher) of XPA
5) Confidence 0.37 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.49 Pain Relevance 0
We report a case of a young man who developed an aggressive Xp11 translocation RCC.
Gene_expression (aggressive) of Xp11 associated with renal cancer
6) Confidence 0.32 Published 2009 Journal Int. J. Urol. Section Abstract Doc Link 19298350 Disease Relevance 0.95 Pain Relevance 0.10

General Comments

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