INT158764

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 8.84
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SPINK5) extracellular region (SPINK5) endoplasmic reticulum (SPINK5)
extracellular matrix organization (SPINK5) cytoplasm (SPINK5)
Anatomy Link Frequency
liver 1
SPINK5 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 11 97.76 Very High Very High Very High
positron emission tomography 7 55.00 Quite High
cytokine 1 53.28 Quite High
Pain 7 50.88 Quite High
imagery 26 41.12 Quite Low
Catecholamine 1 19.16 Low Low
Somatostatin 6 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
lancinating pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroendocrine Cancer 69 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 14 100.00 Very High Very High Very High
Hepatitis C Virus Infection 3 100.00 Very High Very High Very High
Hepatitis 1 100.00 Very High Very High Very High
Syndrome 57 99.56 Very High Very High Very High
Carcinoid 61 99.38 Very High Very High Very High
Disease 37 99.32 Very High Very High Very High
Cancer 69 98.40 Very High Very High Very High
Abdominal Pain 11 97.76 Very High Very High Very High
Metastasis 19 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of hepatitis C virus (HCV) non-structural protein (NS) with Rab1 GTPase-activating protein suggests that viruses are able to subvert host cell machinery in this way because this binding is necessary for HCV replication.
NS Binding (binding) of associated with hepatitis c virus infection and hepatitis
1) Confidence 0.35 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.73 Pain Relevance 0.03
Although carcinoid syndrome has been reported in association with appendiceal NETs in adults, the largest series of these tumors in children failed to show any children with symptoms of carcinoid syndrome [18, 20].
NETs Binding (association) of associated with carcinoid, cancer and syndrome
2) Confidence 0.29 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.53 Pain Relevance 0.18
AIM: To review the current and novel therapeutic options for management of GEP NETs.
NETs Binding (management) of
3) Confidence 0.27 Published 2009 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 19298583 Disease Relevance 0.09 Pain Relevance 0
Currently, screening for NETs is not mandatory in these patients.
NETs Binding (screening) of associated with neuroendocrine cancer
4) Confidence 0.10 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204028 Disease Relevance 1.17 Pain Relevance 0
Though the majority of NETs occur spontaneously, NETs may occur also as part of complex familial endocrine cancer syndromes such as MEN-1, MEN-2, Neurofibromatosis type 1(NFT type 1), Von Hippel Lindau disease, and Carney's Complex [9-11].
NETs Binding (majority) of associated with endocrine gland neoplasms, neuroendocrine cancer, syndrome, von hippel-lindau syndrome, disease and watson syndrome
5) Confidence 0.10 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204028 Disease Relevance 2.69 Pain Relevance 0.09
Primary gastroenteropancreatic NETs can be asymptomatic but may present with obstructive symptoms, and carcinoid syndrome when tumors metastases to the liver with the subsequent release of vasoactive substances responsible of the classical picture of flushing, diarrhea, lacrimation, palpitations, and wheezing.
NETs Binding (present) of in liver associated with heart rate under development, disorders of the lacrimal system, diarrhoea, syndrome, increased venous pressure under development, metastasis, carcinoid, respiratory sounds, neuroendocrine cancer and cancer
6) Confidence 0.10 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204028 Disease Relevance 2.09 Pain Relevance 0.07
This observation was significant given that NETs have not been described previously in any interactions with either C. neoformans or C. gattii.
NETs Binding (interactions) of associated with tumor necrosis factor receptor-associated periodic syndrome
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881863 Disease Relevance 0.53 Pain Relevance 0

General Comments

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