INT158770

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.07
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) transmembrane transport (Trpa1)
lipid metabolic process (Trpv1)
Anatomy Link Frequency
pore 1
Trpv1 (Rattus norvegicus)
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 145 99.62 Very High Very High Very High
TRP channel 39 99.48 Very High Very High Very High
antagonist 23 97.24 Very High Very High Very High
c fibre 72 97.12 Very High Very High Very High
nociceptor 63 94.84 High High
qutenza 65 93.88 High High
Inflammation 199 89.00 High High
withdrawal 64 81.56 Quite High
Spinal cord 3 80.40 Quite High
Pain 25 71.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 208 89.00 High High
Nociception 38 79.40 Quite High
Nervous System Injury 5 55.12 Quite High
Hypersensitivity 9 54.16 Quite High
Pain 28 46.88 Quite Low
Neuropathic Pain 31 5.00 Very Low Very Low Very Low
Hyperalgesia 18 5.00 Very Low Very Low Very Low
Arthritis 15 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 12 5.00 Very Low Very Low Very Low
Ganglion Cysts 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ruthenium Red is a non-competitive TRP channel blocker that blocks both TRPA1 and TRPV1 (Story et al., 2003), and in TRPV1, binds within the channel pore to produce channel block (Garcia-Martinez et al., 2000).
TRPV1 Binding (binds) of TRPA1 in pore associated with trp channel
1) Confidence 0.34 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.23 Pain Relevance 0.57
Given that there are functional interactions between TRPA1 and TRPV1 in vitro and in vivo (Bandell et al., 2004; Bautista et al., 2006; Jeske et al., 2006; Akopian et al., 2007; Ruparel et al., 2007), it is interesting to speculate that a TRPA1/TRPV1 interaction may be responsible for the lower heat thresholds seen in the polymodal C-fibres that express TRPA1 in comparison to those that do not.
TRPV1 Binding (interaction) of TRPA1 associated with c fibre
2) Confidence 0.32 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.61 Pain Relevance 0.58
Given that there are functional interactions between TRPA1 and TRPV1 in vitro and in vivo (Bandell et al., 2004; Bautista et al., 2006; Jeske et al., 2006; Akopian et al., 2007; Ruparel et al., 2007), it is interesting to speculate that a TRPA1/TRPV1 interaction may be responsible for the lower heat thresholds seen in the polymodal C-fibres that express TRPA1 in comparison to those that do not.
TRPV1 Binding (interactions) of TRPA1 associated with c fibre
3) Confidence 0.32 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.62 Pain Relevance 0.62
Given that there are functional interactions between TRPA1 and TRPV1 in vitro and in vivo (Bandell et al., 2004; Bautista et al., 2006; Jeske et al., 2006; Akopian et al., 2007; Ruparel et al., 2007), it is interesting to speculate that a TRPA1/TRPV1 interaction may be responsible for the lower heat thresholds seen in the polymodal C-fibres that express TRPA1 in comparison to those that do not.
TRPV1 Binding (interaction) of TRPA1 associated with c fibre
4) Confidence 0.32 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.61 Pain Relevance 0.58
There are known interactions between TRPV1 and TRPA1 (Bandell et al., 2004; Bautista et al., 2006; Jeske et al., 2006; Akopian et al., 2007; Ruparel et al., 2008), and cinnamaldehyde-evoked heat sensitisation is initiated by TRPA1 but affected by TRPV1 (Bandell et al., 2004).
TRPV1 Binding (interactions) of TRPA1
5) Confidence 0.32 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0 Pain Relevance 0.74
We conclude that DAS, DADS, and DATS are agonist of both TRPA1 and TRPV1 but with high affinity for TRPA1.
TRPV1 Binding (affinity) of TRPA1 associated with agonist
6) Confidence 0.23 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19298793 Disease Relevance 0 Pain Relevance 0.41

General Comments

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